Translating old drugs into new treatments: ribosomal frameshifting as a target for antiviral agents

Programmed ribosomal frameshifting is used by many viruses to regulate the production of structural and enzymatic proteins. Altering the frameshifting efficiencies disrupts the virus life cycle and eliminates or reduces virus production. Ribosomal frameshifting therefore provides a unique target on...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 1998-04, Vol.16 (4), p.190-196
Main Authors: Dinman, Jonathan D, Ruiz-Echevarria, Maria J, Peltz, Stuart W
Format: Article
Language:English
Subjects:
Antiviral Agents - pharmacology
Antiviral drugs
assay
Biological and medical sciences
Biotechnology
drug
frameshifting
Frameshifting, Ribosomal
Fundamental and applied biological sciences. Psychology
Health. Pharmaceutical industry
Industrial applications and implications. Economical aspects
Production of active biomolecules
ribosome
Saccharomyces cerevisiae
translation
virus
Virus Physiological Phenomena
Viruses - drug effects
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Summary:Programmed ribosomal frameshifting is used by many viruses to regulate the production of structural and enzymatic proteins. Altering the frameshifting efficiencies disrupts the virus life cycle and eliminates or reduces virus production. Ribosomal frameshifting therefore provides a unique target on which antiviral agents can function. This article describes a series of rapid assay strategies that have been developed and used to identify potential antiviral agents that target programmed −1 ribosomal frameshifting.
ISSN:0167-7799
1879-3096
DOI:10.1016/S0167-7799(97)01167-0