C-type lectin DC-SIGN: An adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity

The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a type II C-type lectin whose expression is restricted to the most potent antigen-presenting cells (APCs), the dendritic cells (DCs). In recent years, DC-SIGN has gained an exponential increase in attent...

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Bibliographic Details
Published in:Cellular signalling 2010-10, Vol.22 (10), p.1397-1405
Main Authors: Švajger, Urban, Anderluh, Marko, Jeras, Matjaž, Obermajer, Nataša
Format: Article
Language:English
Subjects:
Adhesion
Amino Acid Sequence
Antigen Presentation
Cell Adhesion
Cell Adhesion Molecules - chemistry
Cell Adhesion Molecules - metabolism
Dendritic cells
Dendritic Cells - immunology
Endocytic receptor
Immune modulation
Immunity
Immunologic Surveillance
Lectins, C-Type - chemistry
Lectins, C-Type - metabolism
Migration
Molecular Sequence Data
Pathogen recognition receptor
Receptors, Cell Surface - chemistry
Receptors, Cell Surface - metabolism
Receptors, Pattern Recognition - metabolism
Signal Transduction
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Summary:The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a type II C-type lectin whose expression is restricted to the most potent antigen-presenting cells (APCs), the dendritic cells (DCs). In recent years, DC-SIGN has gained an exponential increase in attention because of its involvement in multiple aspects of immune function. Besides being an adhesion molecule, particularly in binding ICAM-2 and ICAM-3, it is also crucial in recognizing several endogenous and exogenous antigens. Additionally, the intracellular domain of DC-SIGN includes molecular motifs, which enable the activation of signal transduction pathways involving Raf-1 and subsequent modulation of DC-maturation status, through direct modification of nuclear factor Nf-κB in DCs. Upon DC-SIGN engagement by mannose- or fucose-containing oligosaccharides, the latter leads to a tailored Toll-like receptor signalling, resulting in an altered DC-cytokine profile and skewing of Th1/Th2 responses. In this article, we will discuss recent advances on a broad perspective concerning DC-SIGN structure, signalling and immune function.
ISSN:0898-6568
1873-3913
DOI:10.1016/j.cellsig.2010.03.018