Nanotechnological Strategies for Osteoarthritis Diagnosis, Monitoring, Clinical Management, and Regenerative Medicine: Recent Advances and Future Opportunities

Purpose of Review In this review article, we discuss the potential for employing nanotechnological strategies for the diagnosis, monitoring, and clinical management of osteoarthritis (OA) and explore how nanotechnology is being integrated rapidly into regenerative medicine for OA and related osteoar...

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Published in:Current rheumatology reports 2020-04, Vol.22 (4), p.12-12, Article 12
Main Authors: Mohammadinejad, Reza, Ashrafizadeh, Milad, Pardakhty, Abbas, Uzieliene, Ilona, Denkovskij, Jaroslav, Bernotiene, Eiva, Janssen, Lauriane, Lorite, Gabriela S., Saarakkala, Simo, Mobasheri, Ali
Format: Article
Language:English
Subjects:
Cartilage Diseases - therapy
Cartilage, Articular - drug effects
Cartilage, Articular - physiopathology
Humans
Joint Diseases - diagnosis
Joint Diseases - therapy
Medicine
Medicine & Public Health
Nanotechnology - trends
Osteoarthritis (M Goldring
Osteoarthritis (M Goldring, Section Editor)
Osteoarthritis - diagnosis
Osteoarthritis - physiopathology
Osteoarthritis - therapy
Regenerative Medicine - trends
Rheumatology
Section Editor
Topical Collection on Osteoarthritis
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Summary:Purpose of Review In this review article, we discuss the potential for employing nanotechnological strategies for the diagnosis, monitoring, and clinical management of osteoarthritis (OA) and explore how nanotechnology is being integrated rapidly into regenerative medicine for OA and related osteoarticular disorders. Recent Findings We review recent advances in this rapidly emerging field and discuss future opportunities for innovations in enhanced diagnosis, prognosis, and treatment of OA and other osteoarticular disorders, the smart delivery of drugs and biological agents, and the development of biomimetic regenerative platforms to support cell and gene therapies for arresting OA and promoting cartilage and bone repair. Summary Nanotubes, magnetic nanoparticles, and other nanotechnology-based drug and gene delivery systems may be used for targeting molecular pathways and pathogenic mechanisms involved in OA development. Nanocomposites are also being explored as potential tools for promoting cartilage repair. Nanotechnology platforms may be combined with cell, gene, and biological therapies for the development of a new generation of future OA therapeutics. Graphical Abstract
ISSN:1523-3774
1534-6307
DOI:10.1007/s11926-020-0884-z