Variant influenza A (H1N1) virus infection in Canada

Abstract There has been an increase in influenza A variant detections in the US in recent years. In September 2012, an Ontario resident was diagnosed with influenza A (H1N1) variant infection. The demonstrated cross reactivity with the A(H1N1)pdm09 H1 gene CDC realtime PCR suggests that laboratories...

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Bibliographic Details
Published in:Journal of clinical virology 2013-07, Vol.57 (3), p.279-281
Main Authors: Winter, A.L, Eshaghi, A, Farrell, D.J, King, A, Li, A, Li, Y, Gubbay, J.B
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Case description
Case Report
Diagnostic Errors
Genetic Variation
Humans
Infectious Disease
Influenza A virus
Influenza A Virus, H1N1 Subtype - classification
Influenza A Virus, H1N1 Subtype - genetics
Influenza A Virus, H1N1 Subtype - isolation & purification
Influenza, Human - diagnosis
Influenza, Human - virology
Male
Ontario
Polymerase Chain Reaction - methods
Swine-origin influenza A H1N1 virus
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Summary:Abstract There has been an increase in influenza A variant detections in the US in recent years. In September 2012, an Ontario resident was diagnosed with influenza A (H1N1) variant infection. The demonstrated cross reactivity with the A(H1N1)pdm09 H1 gene CDC realtime PCR suggests that laboratories that only use the pdm09 H1 gene PCR to confirm this subtype would incorrectly report this variant as a A(H1N1)pdm09 subtype unless they were doing further molecular investigations.
ISSN:1386-6532
1873-5967
DOI:10.1016/j.jcv.2013.03.011