Utilizing poxviral vectored vaccines for antibody induction—Progress and prospects

Highlights • Poxviral vectors are now regarded as robust tools for B cell and antibody induction. • Antibody responses can be induced against the vector as well as a transgene. • Increasing application is seen in heterologous prime–boost immunization regimes. • Effective veterinary poxviral vaccine...

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Bibliographic Details
Published in:Vaccine 2013-09, Vol.31 (39), p.4223-4230
Main Authors: Draper, Simon J, Cottingham, Matthew G, Gilbert, Sarah C
Format: Article
Language:English
Subjects:
Adenovirus
Allergy and Immunology
ALVAC
Animal models
animal viruses
Animals
antibodies
Antibody
Antibody Formation
antigen-antibody reactions
B cell
B-Lymphocytes - immunology
Canarypox
cell-mediated immunity
clinical trials
Clinical Trials as Topic
DNA vaccine
Genetic Vectors
Good Manufacturing Practice
hemagglutinins
Humans
humoral immunity
Immune system
Immunity, Cellular - genetics
Immunity, Cellular - immunology
Immunity, Humoral
Immunization
Immunogenicity
influenza
Models, Animal
MVA
NYVAC
Poxviridae
Poxviridae - genetics
Poxviridae - immunology
Poxvirus
Prime–boost
Smallpox
surface proteins
transgenes
Vaccination
Vaccines
Vaccines, DNA - immunology
Vaccinia
Viral vector vaccine
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Description
Summary:Highlights • Poxviral vectors are now regarded as robust tools for B cell and antibody induction. • Antibody responses can be induced against the vector as well as a transgene. • Increasing application is seen in heterologous prime–boost immunization regimes. • Effective veterinary poxviral vaccine products are now licensed. • Promising results of antibody induction are being reported in human clinical trials.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.05.091