Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis

• Published in: Experimental and therapeutic medicine 2020-05, Vol.19 (5), p.3419-3424
• Main Authors: Tao, Sen, Zhang, Hong, Zhao, Qiang, Bu, Huaien, Wang, Hongwu, Guo, Hui
• Format: Article
• Language: English
• Subjects: Antioxidants; Antioxidants (Nutrients); Aspartate; Autoimmune diseases; Bilirubin; Care and treatment; Chronic active hepatitis; Correlation analysis; Development and progression; Diseases; Hepatitis; Hospitals; Inflammation; Liver; Liver diseases; Lymphocytes; Medical research; Methods; Necrosis; Oxidative stress; Superoxides; T cells; Tumor necrosis factor-TNF; Tumors; Vitamin D; Vitamins
• ISSN: 1792-0981; 1792-1015
• DOI: 10.3892/etm.2020.8601

Correlation of vitamin D with inflammatory factors, oxidative stress and T cell subsets in patients with autoimmune hepatitis were investigated. Patients with liver diseases (n=635) treated in The Sixth People's Hospital of Qingdao City from March 2015 to January 2018 were selected, among which 80 cases diagnosed with autoimmune hepatitis were included into observation group, and 80 healthy cases were included into control group. Patients with autoimmune hepatitis were further divided into normal 25-hydroxyvitamin D [25-(OH) D] group (n=40) and abnormal 25-(OH) D group (n=40) according to the level of 25-(OH) D, and divided into normal liver function group (n=40) and abnormal liver function group (n=40). 25-(OH) D, liver function, inflammatory factors, oxidative stress level and T cell subsets were compared. In the observation group, levels of 25-(OH) D, superoxide dismutase (SOD), total antioxidant capacity, and T cell subsets were lower than those in the control group (P