Nonlinear Input-Output Functions of Motoneurons

All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2020-01, Vol.35 (1), p.31-39
Main Authors: Binder, Marc D, Powers, Randall K, Heckman, C J
Format: Article
Language:English
Subjects:
Animals
Humans
Membrane Potentials - physiology
Motor Neurons - physiology
Nerve Net - physiology
Review
Sodium - metabolism
Spinal Cord - physiology
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Summary:All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor commands. A major challenge to understanding this transformation has been the striking nonlinear behavior of motoneurons conferred by the activation of persistent inward currents (PICs) mediated by their voltage-gated Na and Ca channels. In this review, we focus on the contribution that these PICs make to motoneuronal discharge and how the nonlinearities they engender impede the construction of a comprehensive model of motor control.
ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00026.2019