Activation of autoreactive T cells by peptides from human pathogens

Activation of autoreactive T cells is a necessary — but not sufficient — step in the development of T cell mediated autoimmunity. Autoreactive T cells can be activated by viral and bacterial peptides that meet the structural requirements for MHC molecule binding and T cell receptor recognition. Due...

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Bibliographic Details
Published in:Current opinion in immunology 1997-12, Vol.9 (6), p.831-838
Main Authors: Hausmann, Stefan, Wucherpfennig, Kai W
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Antigen Presentation
Antigens, Bacterial - genetics
Antigens, Bacterial - immunology
Antigens, Viral - immunology
Autoimmunity - immunology
Epitopes
Humans
Lymphocyte Activation - immunology
Molecular Sequence Data
Receptors, Antigen, T-Cell - genetics
Receptors, Antigen, T-Cell - immunology
Sequence Alignment
T-Lymphocytes - immunology
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Summary:Activation of autoreactive T cells is a necessary — but not sufficient — step in the development of T cell mediated autoimmunity. Autoreactive T cells can be activated by viral and bacterial peptides that meet the structural requirements for MHC molecule binding and T cell receptor recognition. Due to the degenerate nature of MHC class II molecule binding motifs and a certain degree of flexibility in T cell receptor recognition, such microbial peptides have been found to be quite distinct in their primary sequence from the self-peptide they mimic.
ISSN:0952-7915
1879-0372
DOI:10.1016/S0952-7915(97)80186-0