Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study

This study determined whether in vivo positron emission tomography (PET) of arterial inflammation ( F-fluorodeoxyglucose [ F-FDG]) or microcalcification ( F-sodium fluoride [ F-NaF]) could predict restenosis following PTA. Restenosis following lower limb percutaneous transluminal angioplasty (PTA) i...

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Bibliographic Details
Published in:JACC. Cardiovascular imaging 2020-04, Vol.13 (4), p.1008-1017
Main Authors: Chowdhury, Mohammed M, Tarkin, Jason M, Albaghdadi, Mazen S, Evans, Nicholas R, Le, Elizabeth P V, Berrett, Thomas B, Sadat, Umar, Joshi, Francis R, Warburton, Elizabeth A, Buscombe, John R, Hayes, Paul D, Dweck, Marc R, Newby, David E, Rudd, James H F, Coughlin, Patrick A
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Angioplasty, Balloon - adverse effects
Female
Femoral Artery - diagnostic imaging
Femoral Artery - physiopathology
Fluorodeoxyglucose F18 - administration & dosage
Humans
Male
Middle Aged
Peripheral Arterial Disease - diagnostic imaging
Peripheral Arterial Disease - physiopathology
Peripheral Arterial Disease - therapy
Plaque, Atherosclerotic
Positron-Emission Tomography
Predictive Value of Tests
Prospective Studies
Radiopharmaceuticals - administration & dosage
Recurrence
Risk Factors
Sodium Fluoride - administration & dosage
Time Factors
Treatment Outcome
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Summary:This study determined whether in vivo positron emission tomography (PET) of arterial inflammation ( F-fluorodeoxyglucose [ F-FDG]) or microcalcification ( F-sodium fluoride [ F-NaF]) could predict restenosis following PTA. Restenosis following lower limb percutaneous transluminal angioplasty (PTA) is common, unpredictable, and challenging to treat. Currently, it is impossible to predict which patient will suffer from restenosis following angioplasty. In this prospective observational cohort study, 50 patients with symptomatic peripheral arterial disease underwent F-FDG and F-NaF PET/computed tomography (CT) imaging of the superficial femoral artery before and 6 weeks after angioplasty. The primary outcome was arterial restenosis at 12 months. Forty subjects completed the study protocol with 14 patients (35%) reaching the primary outcome of restenosis. The baseline activities of femoral arterial inflammation ( F-FDG tissue-to-background ratio [TBR] 2.43 [interquartile range (IQR): 2.29 to 2.61] vs. 1.63 [IQR: 1.52 to 1.78]; p 
ISSN:1936-878X
1876-7591
DOI:10.1016/j.jcmg.2019.03.031