Antipsychotic drug exposure and risk of myocardial infarction

Patients experiencing psychoses and in need of antipsychotic agents may be exposed to a higher risk of myocardial infarction (MI) than the general population. As there have been no randomised studies investigating this association, a recent systematic review and meta-analysis included all observatio...

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Bibliographic Details
Published in:Epidemiology and psychiatric sciences 2017-02, Vol.26 (1), p.18-21
Main Authors: Barbui, C., Gastaldon, C., Papola, D., Ostuzzi, G.
Format: Article
Language:English
Subjects:
Antipsychotic Agents - adverse effects
Antipsychotic Agents - therapeutic use
Drug therapy
Epidemiology for Clinical Psychopharmacology
Heart attacks
Humans
Incidence
Myocardial Infarction - chemically induced
Neuroses
Psychopharmacology
Psychotic Disorders
Psychotropic drugs
Risk Factors
Systematic review
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Summary:Patients experiencing psychoses and in need of antipsychotic agents may be exposed to a higher risk of myocardial infarction (MI) than the general population. As there have been no randomised studies investigating this association, a recent systematic review and meta-analysis included all observational studies that compared the incidence of MI among patients receiving antipsychotics v. no treatment. It found nine studies and calculated that the odds (risk) for developing MI were 1.88-fold higher in antipsychotic users compared with individuals who had not taken antipsychotic drugs. In this commentary, the results of this systematic review are discussed in view of their clinical implications for everyday clinical practice.
ISSN:2045-7960
2045-7979
DOI:10.1017/S204579601600086X