Asymptomatic Hepatic Sequestration with Extreme Hyperbilirubinemia in an Adult Homozygous Sickle Cell Patient

It has been estimated that there are greater than 100,000 individuals in the US with sickle cell disease. Hepatic sequestration is a known sequelae of sickle cell disease that rarely leads to extreme hyperbilirubinemia (total serum bilirubin greater than 20 mg/dl). Our 26-year-old male patient, thou...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-03, Vol.12 (3), p.e7210
Main Authors: Raza, Syed Musa, Faraji, Mehdi, Khan, Omar, Shaukat, Rimsha
Format: Article
Language:English
Subjects:
Abdomen
Blood
Case reports
Cytomegalovirus
Erythrocytes
Gastroenterology
Health sciences
Hematology
Hepatitis
Internal Medicine
Iron
Laboratories
Liver
Pain
Patients
Sickle cell anemia
Sickle cell disease
Ultrasonic imaging
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Summary:It has been estimated that there are greater than 100,000 individuals in the US with sickle cell disease. Hepatic sequestration is a known sequelae of sickle cell disease that rarely leads to extreme hyperbilirubinemia (total serum bilirubin greater than 20 mg/dl). Our 26-year-old male patient, though compliant with regular transfusion exchanges, presented with hepatic sequestration, with minimal symptoms and hyperbilirubinemia up to approximately 40 mg/dl. The severity of asymptomatic hepatic sequestration seen in our patient has never been reported in the literature. This mandates a low threshold to screen for sickle cell complications and promptly treating these patients admitted to the hospital with exchange transfusions.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.7210