PPARs as Metabolic Regulators in the Liver: Lessons from Liver-Specific PPAR-Null Mice

Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis. PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic steatosis, steatohepatitis, steatofibrosis, and...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-03, Vol.21 (6), p.2061
Main Authors: Wang, Yaping, Nakajima, Takero, Gonzalez, Frank J, Tanaka, Naoki
Format: Article
Language:English
Subjects:
Abnormalities
Adipocytes
Animals
Biosynthesis
Dehydrogenases
Disease
Energy balance
Energy Metabolism
Enzymes
Fatty liver
Gene expression
Gene Expression Regulation
Growth factors
Homeostasis
Humans
Insulin
Ligands
Lipid Metabolism
Lipids
Liver
Liver - metabolism
Liver cancer
Localization
Metabolism
Metabolites
Mice
Mice, Knockout
Multigene Family
Organ Specificity - genetics
Organs
Oxidation
Peroxisome proliferator-activated receptors
Peroxisome Proliferator-Activated Receptors - genetics
Peroxisome Proliferator-Activated Receptors - metabolism
Protein Isoforms
Regulators
Review
Rodents
Roles
Signal Transduction
Steatosis
Triglycerides
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Summary:Peroxisome proliferator-activated receptor (PPAR) α, β/δ, and γ modulate lipid homeostasis. PPARα regulates lipid metabolism in the liver, the organ that largely controls whole-body nutrient/energy homeostasis, and its abnormalities may lead to hepatic steatosis, steatohepatitis, steatofibrosis, and liver cancer. PPARβ/δ promotes fatty acid β-oxidation largely in extrahepatic organs, and PPARγ stores triacylglycerol in adipocytes. Investigations using liver-specific PPAR-disrupted mice have revealed major but distinct contributions of the three PPARs in the liver. This review summarizes the findings of liver-specific PPAR-null mice and discusses the role of PPARs in the liver.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21062061