Role of Neutrophils and Myeloid-Derived Suppressor Cells in Glioma Progression and Treatment Resistance

Recent efforts in brain tumor research have been directed towards the modulation of the immune system for therapeutic interventions. Several human cancers, including gliomas, are infiltrated with immune cell types-including neutrophils and myeloid-derived suppressor cells-that contribute to tumor pr...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-03, Vol.21 (6), p.1954
Main Authors: Khan, Sabbir, Mittal, Sandeep, McGee, Kain, Alfaro-Munoz, Kristin D, Majd, Nazanin, Balasubramaniyan, Veerakumar, de Groot, John F
Format: Article
Language:English
Subjects:
Antitumor activity
Brain cancer
Brain tumors
Chemokines
Chemotherapy
Cytokines
Gene expression
Glioma
Glioma cells
Immune system
Invasiveness
Kinases
Leukocytes (neutrophilic)
Ligands
Medical prognosis
Nervous system
Neutrophils
Review
Suppressor cells
Therapeutic applications
Treatment resistance
Tumors
Vascular endothelial growth factor
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Summary:Recent efforts in brain tumor research have been directed towards the modulation of the immune system for therapeutic interventions. Several human cancers, including gliomas, are infiltrated with immune cell types-including neutrophils and myeloid-derived suppressor cells-that contribute to tumor progression, invasiveness, and treatment resistance. The role of tumor-associated neutrophils and myeloid-derived suppressor cells in cancer biology remains elusive, as these cells can exert a multitude of pro-tumor and antitumor effects. In this review, we provide the current understanding and novel insights on the role of neutrophils and myeloid-derived suppressor cells in glioma progression and treatment resistance, as well as the mechanisms of pleiotropic behaviors in these cells during disease progression, with an emphasis on possible strategies to reprogram these cells towards their antitumor actions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21061954