Sepsis-Associated Encephalopathy: From Delirium to Dementia?

Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality. Moreover, in the chronic phase, more than 50% of surviving patients suffer from severe and long...

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Bibliographic Details
Published in:Journal of clinical medicine 2020-03, Vol.9 (3), p.703
Main Authors: Chung, Ha-Yeun, Wickel, Jonathan, Brunkhorst, Frank M, Geis, Christian
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animal cognition
Clinical medicine
Cognitive ability
Coma
Cytokines
Delirium
Dementia
Hospitals
Illnesses
Infections
Metabolism
Mortality
Pathophysiology
Patients
Physiology
Review
Sepsis
Veins & arteries
Vitamin deficiency
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Summary:Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality. Moreover, in the chronic phase, more than 50% of surviving patients suffer from severe and long-term cognitive deficits compromising their daily quality of life and placing an immense burden on primary caregivers. Due to a growing number of sepsis survivors, these long-lasting deficits are increasingly relevant. Despite the high incidence and clinical relevance, the pathomechanisms of acute and chronic stages in sepsis-associated encephalopathy are only incompletely understood, and no specific therapeutic options are yet available. Here, we review the emergence of sepsis-associated encephalopathy from initial clinical presentation to long-term cognitive impairment in sepsis survivors and summarize pathomechanisms potentially contributing to the development of sepsis-associated encephalopathy.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm9030703