The Role of Leptin Levels in Adaptation to Cold Climates

Currently, adipose tissue is considered an endocrine organ that produces hormone-active substances, including leptin, which can play a key role in thermoregulation processes. Therefore, we performed a meta-analysis to investigate the influence of the climatic environment on leptin levels. A systemat...

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Bibliographic Details
Published in:International journal of environmental research and public health 2020-03, Vol.17 (6), p.1854
Main Authors: Nikanorova, Alena A, Barashkov, Nikolay A, Nakhodkin, Sergey S, Pshennikova, Vera G, Solovyev, Aisen V, Romanov, Georgii P, Kuzmina, Sargylana S, Sazonov, Nikolay N, Burtseva, Tatyana E, Odland, Jon Øyvind, Fedorova, Sardana A
Format: Article
Language:English
Subjects:
Adipose tissue
Age
Body mass index
Body temperature
Climate
Cold
Cold weather
Females
Heat
Leptin
Males
Meta-analysis
Physiology
Proteins
Studies
Subgroups
Temperature requirements
Thermogenesis
Thermoregulation
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Summary:Currently, adipose tissue is considered an endocrine organ that produces hormone-active substances, including leptin, which can play a key role in thermoregulation processes. Therefore, we performed a meta-analysis to investigate the influence of the climatic environment on leptin levels. A systematic literature search in the databases was carried out on 10 January 2020. Finally, 22 eligible articles were included in the current meta-analysis and a total of 13,320 participants were covered in the final analysis. It was shown that males of the "North" subgroup demonstrated significantly higher levels of leptin (10.02 ng/mL; CI: 7.92-12.13) than males of the "South" subgroup (4.9 ng/mL; CI: 3.71-6.25) ( = 0.0001). On the contrary, in the female group, a similar pattern was not detected ( = 0.91). Apparently, in order to maintain body temperature, higher leptin levels are required. The results of the study indicate that such effects are most pronounced in males and to a smaller extent in females, apparently due to a relatively high initial concentration of leptin in females. The correlation between leptin levels and climatic environment data support the hypothesis of leptin-mediated thermoregulation as an adaptive mechanism to cold climates.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph17061854