Genomic Characterization of Newly Completed Genomes of Botulinum Neurotoxin-Producing Species from Argentina, Australia, and Africa

Abstract Botulinum neurotoxin-producing clostridia are diverse in the types of toxins they produce as well as in their overall genomic composition. They are globally distributed, with prevalent species and toxin types found within distinct geographic regions, but related strains containing the same...

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Bibliographic Details
Published in:Genome biology and evolution 2020-03, Vol.12 (3), p.229-242
Main Authors: Smith, Theresa J, Xie, Gary, Williamson, Charles H D, Hill, Karen K, Fernández, Rafael A, Sahl, Jason W, Keim, Paul, Johnson, Shannon L
Format: Article
Language:English
Subjects:
Africa
Argentina
Australia
BASIC BIOLOGICAL SCIENCES
biological science
botulinum neurotoxin producing
Botulinum Toxins - biosynthesis
Botulinum Toxins - genetics
clostridia
Clostridium - classification
Clostridium - genetics
Clostridium - metabolism
Genome, Bacterial
Genomics
Phylogeny
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Summary:Abstract Botulinum neurotoxin-producing clostridia are diverse in the types of toxins they produce as well as in their overall genomic composition. They are globally distributed, with prevalent species and toxin types found within distinct geographic regions, but related strains containing the same toxin types may also be located on distinct continents. The mechanisms behind the spread of these bacteria and the independent movements of their bont genes may be understood through examination of their genetic backgrounds. The generation of 15 complete genomic sequences from bacteria isolated in Argentina, Australia, and Africa allows for a thorough examination of genome features, including overall relationships, bont gene cluster locations and arrangements, and plasmid comparisons, in bacteria isolated from various areas in the southern hemisphere. Insights gained from these examinations provide an understanding of the mechanisms behind the independent movements of these elements among distinct species.
ISSN:1759-6653
1759-6653
DOI:10.1093/gbe/evaa043