Integrating Pharmacokinetics and Pharmacodynamics in Operational Research to End Tuberculosis

Abstract Tuberculosis (TB) elimination requires innovative approaches. The new Global Tuberculosis Network (GTN) aims to conduct research on key unmet therapeutic and diagnostic needs in the field of TB elimination using multidisciplinary, multisectorial approaches. The TB Pharmacology section withi...

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Bibliographic Details
Published in:Clinical infectious diseases 2020-04, Vol.70 (8), p.1774-1780
Main Authors: Alffenaar, Jan-Willem C, Gumbo, Tawanda, Dooley, Kelly E, Peloquin, Charles A, Mcilleron, Helen, Zagorski, Andre, Cirillo, Daniela M, Heysell, Scott K, Silva, Denise Rossato, Migliori, Giovanni Battista
Format: Article
Language:English
Subjects:
Antitubercular Agents - pharmacology
Antitubercular Agents - therapeutic use
Humans
Operations Research
Prospective Studies
Tuberculosis - drug therapy
Tuberculosis - prevention & control
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Summary:Abstract Tuberculosis (TB) elimination requires innovative approaches. The new Global Tuberculosis Network (GTN) aims to conduct research on key unmet therapeutic and diagnostic needs in the field of TB elimination using multidisciplinary, multisectorial approaches. The TB Pharmacology section within the new GTN aims to detect and study the current knowledge gaps, test potential solutions using human pharmacokinetics informed through preclinical infection systems, and return those findings to the bedside. Moreover, this approach would allow prospective identification and validation of optimal shorter therapeutic durations with new regimens. Optimized treatment using available and repurposed drugs may have an increased impact when prioritizing a person-centered approach and acknowledge the importance of age, gender, comorbidities, and both social and programmatic environments. In this viewpoint article, we present an in-depth discussion on how TB pharmacology and the related strategies will contribute to TB elimination. An enhanced understanding of tuberculosis (TB) pharmacology aims to use pharmacokinetics and pharmacodynamics, operational research, and therapeutic drug monitoring to support TB elimination.
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciz942