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Capsosiphon fulvescens Glycoproteins Enhance Probiotics-Induced Cognitive Improvement in Aged Rats
Aging-induced cognitive dysfunction can be regulated by probiotics through bidirectional communication with the brain. This study aimed to investigate whether glycoproteins (Cf-hGP) enhanced probiotic-induced improvement of memory in aged rats and the underlying mechanism in the dorsal hippocampus....
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| Published in: | Nutrients 2020-03, Vol.12 (3), p.837 |
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| description | Aging-induced cognitive dysfunction can be regulated by probiotics through bidirectional communication with the brain. This study aimed to investigate whether
glycoproteins (Cf-hGP) enhanced probiotic-induced improvement of memory in aged rats and the underlying mechanism in the dorsal hippocampus. Cf-hGP were isolated using lectin resin. Cf-hGP (15 mg/kg/day) and/or
(
) (10
CFU/rat/day) were orally administered once a day for 4 weeks. Co-treatment with Cf-hGP and
synergistically improved spatial memory in aged rats, which was overturned by functional blocks of brain-derived neurotrophic factor (BDNF) signaling. Increases in BDNF expression and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation were accompanied by mono- and/or co-administration in the dorsal hippocampus, while c-Jun N-terminal kinase (JNK) phosphorylation and glucose-regulated protein 78 expression were decreased. These synergistic effects were downregulated by blocks of BDNF/Nrf2-mediated signaling. In particular, co-treatment, not mono-treatment, reduced phosphorylation of eukaryotic elongation factor 2 (eEF2) regulated by eEF2 kinase and protein phosphatase 2A. Additionally, co-treatment downregulated the interaction between eEF2 kinase and JNK. These data demonstrated that cognitive impairment in aged rats was synergistically diminished by co-treatment with Cf-hGP and
through BDNF-mediated regulation of Nrf2 and eEF2 signaling pathways in the dorsal hippocampus. |
| doi_str_mv | 10.3390/nu12030837 |
| format | article |
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glycoproteins (Cf-hGP) enhanced probiotic-induced improvement of memory in aged rats and the underlying mechanism in the dorsal hippocampus. Cf-hGP were isolated using lectin resin. Cf-hGP (15 mg/kg/day) and/or
(
) (10
CFU/rat/day) were orally administered once a day for 4 weeks. Co-treatment with Cf-hGP and
synergistically improved spatial memory in aged rats, which was overturned by functional blocks of brain-derived neurotrophic factor (BDNF) signaling. Increases in BDNF expression and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation were accompanied by mono- and/or co-administration in the dorsal hippocampus, while c-Jun N-terminal kinase (JNK) phosphorylation and glucose-regulated protein 78 expression were decreased. These synergistic effects were downregulated by blocks of BDNF/Nrf2-mediated signaling. In particular, co-treatment, not mono-treatment, reduced phosphorylation of eukaryotic elongation factor 2 (eEF2) regulated by eEF2 kinase and protein phosphatase 2A. Additionally, co-treatment downregulated the interaction between eEF2 kinase and JNK. These data demonstrated that cognitive impairment in aged rats was synergistically diminished by co-treatment with Cf-hGP and
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glycoproteins (Cf-hGP) enhanced probiotic-induced improvement of memory in aged rats and the underlying mechanism in the dorsal hippocampus. Cf-hGP were isolated using lectin resin. Cf-hGP (15 mg/kg/day) and/or
(
) (10
CFU/rat/day) were orally administered once a day for 4 weeks. Co-treatment with Cf-hGP and
synergistically improved spatial memory in aged rats, which was overturned by functional blocks of brain-derived neurotrophic factor (BDNF) signaling. Increases in BDNF expression and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation were accompanied by mono- and/or co-administration in the dorsal hippocampus, while c-Jun N-terminal kinase (JNK) phosphorylation and glucose-regulated protein 78 expression were decreased. These synergistic effects were downregulated by blocks of BDNF/Nrf2-mediated signaling. In particular, co-treatment, not mono-treatment, reduced phosphorylation of eukaryotic elongation factor 2 (eEF2) regulated by eEF2 kinase and protein phosphatase 2A. Additionally, co-treatment downregulated the interaction between eEF2 kinase and JNK. These data demonstrated that cognitive impairment in aged rats was synergistically diminished by co-treatment with Cf-hGP and
through BDNF-mediated regulation of Nrf2 and eEF2 signaling pathways in the dorsal hippocampus.</description><subject>Administration, Oral</subject><subject>Aging</subject><subject>Aging (artificial)</subject><subject>Aging - psychology</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Biomarkers</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>c-Jun protein</subject><subject>Capsosiphon fulvescens</subject><subject>Chlorophyta - chemistry</subject><subject>Cognition - drug effects</subject><subject>Cognitive ability</subject><subject>Cognitive Aging</subject><subject>Cognitive Dysfunction - drug therapy</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Disease Models, Animal</subject><subject>Elongation</subject><subject>Gene expression</subject><subject>Glycoproteins</subject><subject>Glycoproteins - chemistry</subject><subject>Glycoproteins - pharmacology</subject><subject>Hippocampus</subject><subject>Immunohistochemistry</subject><subject>JNK protein</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Lactobacillus plantarum</subject><subject>Male</subject><subject>MAP Kinase Kinase 4 - metabolism</subject><subject>Memory</subject><subject>Memory tasks</subject><subject>Microbiota</subject><subject>Morris Water Maze Test</subject><subject>NF-E2-Related Factor 2 - metabolism</subject><subject>Oral administration</subject><subject>Phosphoprotein phosphatase</subject><subject>Phosphorylation</subject><subject>Probiotics</subject><subject>Probiotics - administration & dosage</subject><subject>Proteins</subject><subject>Rats</subject><subject>Spatial analysis</subject><subject>Spatial memory</subject><subject>Stress</subject><subject>Synergistic effect</subject><subject>Transcription factors</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkd9LwzAQx4Mobkxf_AOk4IsI1TRJk_ZFkDF1MFBk7yFJ0y2jTWrSDvbfm6HOH_dyd9yHL3f3BeAig7cYl_DODhmCGBaYHYExggyllBJ8_KsegfMQNnAfDDKKT8EII0RyWOIxkFPRBRdMt3Y2qYdmq4PSNiRPzU65zrtem9jN7FpYpZNX76RxvVEhndtqULpKpm5lTW-2Opm3kd_qVts-MTZ5WMXpm-jDGTipRRP0-VeegOXjbDl9ThcvT_PpwyJVBNI-ZTJXDEtNWF2zikDCaCElppWuSiUlKXGuC0oFpJLSChJRZVjWCtWMlPsXTMD9p2w3yFZX8Yrei4Z33rTC77gThv-dWLPmK7flLCM0xzQKXH8JePc-6NDz1sRnNI2w2g2BI1xQxIqCFBG9-odu3OBtvI4jgmDGaJ5lkbr5pJR3IXhdH5bJIN-bx3_Mi_Dl7_UP6LdV-AOOGZY6</recordid><startdate>20200320</startdate><enddate>20200320</enddate><creator>Oh, Jeong Hwan</creator><creator>Nam, Taek-Jeong</creator><creator>Choi, Youn Hee</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5954-6935</orcidid><orcidid>https://orcid.org/0000-0002-0091-7893</orcidid></search><sort><creationdate>20200320</creationdate><title>Capsosiphon fulvescens Glycoproteins Enhance Probiotics-Induced Cognitive Improvement in Aged Rats</title><author>Oh, Jeong Hwan ; Nam, Taek-Jeong ; Choi, Youn Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-7b5c73be47ff7d404768bb36ded9cbb4935e866a06b66d04ad13bfc2f7491203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Administration, Oral</topic><topic>Aging</topic><topic>Aging (artificial)</topic><topic>Aging - psychology</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>Biomarkers</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>c-Jun protein</topic><topic>Capsosiphon fulvescens</topic><topic>Chlorophyta - chemistry</topic><topic>Cognition - drug effects</topic><topic>Cognitive ability</topic><topic>Cognitive Aging</topic><topic>Cognitive Dysfunction - drug therapy</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Disease Models, Animal</topic><topic>Elongation</topic><topic>Gene expression</topic><topic>Glycoproteins</topic><topic>Glycoproteins - chemistry</topic><topic>Glycoproteins - pharmacology</topic><topic>Hippocampus</topic><topic>Immunohistochemistry</topic><topic>JNK protein</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Lactobacillus plantarum</topic><topic>Male</topic><topic>MAP Kinase Kinase 4 - metabolism</topic><topic>Memory</topic><topic>Memory tasks</topic><topic>Microbiota</topic><topic>Morris Water Maze Test</topic><topic>NF-E2-Related Factor 2 - metabolism</topic><topic>Oral administration</topic><topic>Phosphoprotein phosphatase</topic><topic>Phosphorylation</topic><topic>Probiotics</topic><topic>Probiotics - administration & dosage</topic><topic>Proteins</topic><topic>Rats</topic><topic>Spatial analysis</topic><topic>Spatial memory</topic><topic>Stress</topic><topic>Synergistic effect</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oh, Jeong Hwan</creatorcontrib><creatorcontrib>Nam, Taek-Jeong</creatorcontrib><creatorcontrib>Choi, Youn Hee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oh, Jeong Hwan</au><au>Nam, Taek-Jeong</au><au>Choi, Youn Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capsosiphon fulvescens Glycoproteins Enhance Probiotics-Induced Cognitive Improvement in Aged Rats</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2020-03-20</date><risdate>2020</risdate><volume>12</volume><issue>3</issue><spage>837</spage><pages>837-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Aging-induced cognitive dysfunction can be regulated by probiotics through bidirectional communication with the brain. This study aimed to investigate whether
glycoproteins (Cf-hGP) enhanced probiotic-induced improvement of memory in aged rats and the underlying mechanism in the dorsal hippocampus. Cf-hGP were isolated using lectin resin. Cf-hGP (15 mg/kg/day) and/or
(
) (10
CFU/rat/day) were orally administered once a day for 4 weeks. Co-treatment with Cf-hGP and
synergistically improved spatial memory in aged rats, which was overturned by functional blocks of brain-derived neurotrophic factor (BDNF) signaling. Increases in BDNF expression and nuclear factor erythroid 2-related factor 2 (Nrf2) phosphorylation were accompanied by mono- and/or co-administration in the dorsal hippocampus, while c-Jun N-terminal kinase (JNK) phosphorylation and glucose-regulated protein 78 expression were decreased. These synergistic effects were downregulated by blocks of BDNF/Nrf2-mediated signaling. In particular, co-treatment, not mono-treatment, reduced phosphorylation of eukaryotic elongation factor 2 (eEF2) regulated by eEF2 kinase and protein phosphatase 2A. Additionally, co-treatment downregulated the interaction between eEF2 kinase and JNK. These data demonstrated that cognitive impairment in aged rats was synergistically diminished by co-treatment with Cf-hGP and
through BDNF-mediated regulation of Nrf2 and eEF2 signaling pathways in the dorsal hippocampus.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32245093</pmid><doi>10.3390/nu12030837</doi><orcidid>https://orcid.org/0000-0002-5954-6935</orcidid><orcidid>https://orcid.org/0000-0002-0091-7893</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Nutrients, 2020-03, Vol.12 (3), p.837 |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Administration, Oral Aging Aging (artificial) Aging - psychology Animal cognition Animals Biomarkers Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - metabolism c-Jun protein Capsosiphon fulvescens Chlorophyta - chemistry Cognition - drug effects Cognitive ability Cognitive Aging Cognitive Dysfunction - drug therapy Cognitive Dysfunction - etiology Disease Models, Animal Elongation Gene expression Glycoproteins Glycoproteins - chemistry Glycoproteins - pharmacology Hippocampus Immunohistochemistry JNK protein Kinases Laboratory animals Lactobacillus plantarum Male MAP Kinase Kinase 4 - metabolism Memory Memory tasks Microbiota Morris Water Maze Test NF-E2-Related Factor 2 - metabolism Oral administration Phosphoprotein phosphatase Phosphorylation Probiotics Probiotics - administration & dosage Proteins Rats Spatial analysis Spatial memory Stress Synergistic effect Transcription factors |
| title | Capsosiphon fulvescens Glycoproteins Enhance Probiotics-Induced Cognitive Improvement in Aged Rats |
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