Correlation of circulating ANGPTL5 levels with obesity, high sensitivity C-reactive protein and oxidized low-density lipoprotein in adolescents

Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to regulate triglyceride metabolism and is increased in obesity and diabetes. However, its role in metabolic diseases in adolescents is not well-stud...

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Bibliographic Details
Published in:Scientific reports 2020-04, Vol.10 (1), p.6330, Article 6330
Main Authors: Hammad, Maha M., Abu-Farha, Mohamed, Al-Taiar, Abdullah, Alam-Eldin, Nada, Al-Sabah, Reem, Shaban, Lemia, Al-Mulla, Fahd, Abubaker, Jehad, Rahman, Abdur
Format: Article
Language:English
Subjects:
692/163/2743/2099
692/163/2743/393
Adolescent
Adolescents
Angiopoietin
Angiopoietin-like Proteins - blood
Angiopoietin-like Proteins - metabolism
Biomarkers - blood
Biomarkers - metabolism
Body weight
C-reactive protein
C-Reactive Protein - analysis
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - prevention & control
Child
Cross-Sectional Studies
Diabetes mellitus
Female
Health risk assessment
Health risks
Humanities and Social Sciences
Humans
Kuwait - epidemiology
Lipoproteins, LDL - blood
Lipoproteins, LDL - metabolism
Low density lipoprotein
Male
Metabolic disorders
multidisciplinary
Obesity
Obesity - blood
Obesity - complications
Obesity - epidemiology
Obesity - metabolism
Overweight
Overweight - blood
Overweight - complications
Overweight - epidemiology
Overweight - metabolism
Prevalence
Risk Factors
Schools
Science
Science (multidisciplinary)
Teenagers
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Summary:Angiopoietin-like proteins (ANGPTL) is a family of eight members known to play an important role in metabolic diseases. Of these, ANGPTL5 is suggested to regulate triglyceride metabolism and is increased in obesity and diabetes. However, its role in metabolic diseases in adolescents is not well-studied. In this study, we tested the hypothesis of a positive association between plasma ANGPTL5, and obesity, high sensitivity C-reactive protein (HsCRP) and oxidized low-density lipoprotein (Ox-LDL) in adolescents. Adolescents (N = 431; age 11–14 years) were randomly selected from middle schools in Kuwait. Obesity was classified by the BMI-for-age based on the WHO growth charts. Plasma ANGPTL5, HsCRP, and Ox-LDL were measured using ELISA. The prevalence of overweight and obesity was 20.65% and 33.18%, respectively. Mean (SD) plasma ANGPTL5 levels were significantly higher in obese, compared with overweight and normal-weight adolescents (23.05 (8.79) vs 18.39 (7.08) ng/mL, and 18.26 (6.95) ng/ml, respectively). ANGPTL5 was positively associated with both HsCRP (ρ=0.27, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-63076-7