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Quantitative Comparative Proteomics Reveals Candidate Biomarkers for the Early Prediction of Gestational Diabetes Mellitus: A Preliminary Study

To identify differentially expressed proteins (DEPs) in 1 trimester maternal plasma between pregnant women at risk for gestational diabetes mellitus (GDM) and uncomplicated controls. First-trimester plasma from five women who developed GDM and five from non-diabetic ones were analyzed using isobaric...

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Bibliographic Details
Published in:In vivo (Athens) 2020-03, Vol.34 (2), p.517-525
Main Authors: Mavreli, Danai, Evangelinakis, Nikolas, Papantoniou, Nikolas, Kolialexi, Aggeliki
Format: Article
Language:English
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Summary:To identify differentially expressed proteins (DEPs) in 1 trimester maternal plasma between pregnant women at risk for gestational diabetes mellitus (GDM) and uncomplicated controls. First-trimester plasma from five women who developed GDM and five from non-diabetic ones were analyzed using isobaric tag for relative and absolute quantitation - labeled proteomics. Enzyme-linked immunosorbent assay was further applied in an independent cohort of 25 GDM cases and 25 controls for verification. Prenylcysteine oxidase 1 (PCYOX1), beta-ala-his dipeptidase (CNDP1), extracellular matrix protein 1 (ECM1), basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2), thrombospondin-4 (TSP-4) demonstrated significant differences in expression between the two groups (p
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.11803