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Quantitative Comparative Proteomics Reveals Candidate Biomarkers for the Early Prediction of Gestational Diabetes Mellitus: A Preliminary Study
To identify differentially expressed proteins (DEPs) in 1 trimester maternal plasma between pregnant women at risk for gestational diabetes mellitus (GDM) and uncomplicated controls. First-trimester plasma from five women who developed GDM and five from non-diabetic ones were analyzed using isobaric...
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Published in: | In vivo (Athens) 2020-03, Vol.34 (2), p.517-525 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | To identify differentially expressed proteins (DEPs) in 1
trimester maternal plasma between pregnant women at risk for gestational diabetes mellitus (GDM) and uncomplicated controls.
First-trimester plasma from five women who developed GDM and five from non-diabetic ones were analyzed using isobaric tag for relative and absolute quantitation - labeled proteomics. Enzyme-linked immunosorbent assay was further applied in an independent cohort of 25 GDM cases and 25 controls for verification.
Prenylcysteine oxidase 1 (PCYOX1), beta-ala-his dipeptidase (CNDP1), extracellular matrix protein 1 (ECM1), basement membrane-specific heparan sulfate proteoglycan core protein (HSPG2), thrombospondin-4 (TSP-4) demonstrated significant differences in expression between the two groups (p |
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ISSN: | 0258-851X 1791-7549 |
DOI: | 10.21873/invivo.11803 |