Substrate‐Induced Self‐Assembly of Cooperative Catalysts

Dissipative self‐assembly processes in nature rely on chemical fuels that activate proteins for assembly through the formation of a noncovalent complex. The catalytic activity of the assemblies causes fuel degradation, resulting in the formation of an assembly in a high‐energy, out‐of‐equilibrium st...

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Bibliographic Details
Published in:Angewandte Chemie 2018-12, Vol.130 (50), p.16707-16712
Main Authors: Solís Muñana, Pablo, Ragazzon, Giulio, Dupont, Julien, Ren, Chloe Z.‐J., Prins, Leonard J., Chen, Jack L.‐Y.
Format: Article
Language:English
Subjects:
Amphiphile
Assemblies
Assembly
Biomimetische Katalyse
Catalysis
Catalysts
Catalytic activity
Chemical fuels
Chemistry
Dissipative Selbstorganisation
Kooperative Katalyse
Organic chemistry
Proteins
Substrates
Systemchemie
Zuschrift
Zuschriften
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Summary:Dissipative self‐assembly processes in nature rely on chemical fuels that activate proteins for assembly through the formation of a noncovalent complex. The catalytic activity of the assemblies causes fuel degradation, resulting in the formation of an assembly in a high‐energy, out‐of‐equilibrium state. Herein, we apply this concept to a synthetic system and demonstrate that a substrate can induce the formation of vesicular assemblies, which act as cooperative catalysts for cleavage of the same substrate. Selbstzerstörung mit guten Grund: Ein Substrat induziert die Selbstorganisation eines kooperativen Katalysators, der wiederum die Spaltung des Substrats bewirkt. Die Natur nutzt die gleiche Strategie, um energiereiche Strukturen wie Mikrotubuli zu erhalten und Nichtgleichgewichtsphänomene anzutreiben.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201810891