Hepatoprotective Effect of Oleuropein-Rich Extract from Olive Leaves against Cadmium-Induced Toxicity in Mice

Cadmium (Cd) is a harmful pollutant which mainly affects the liver and kidney. In this work, we investigated the hepatoprotective effects of olive leaf extract based on oleuropein against hepatic cadmium toxicity in mice. Three groups of animals were used: the first one served as the control (C); th...

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Bibliographic Details
Published in:BioMed research international 2020, Vol.2020 (2020), p.1-9
Main Authors: Sayadi, Sami, Choura, Sirine, Bouallagui, Zouhaier, Fki, Ines, Feryeni, Anwar, Mahmoudi, Asma, Jemai, Hedya, Chamkha, Mohamed
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Analysis
Animals
Antioxidants
Antioxidants - pharmacology
Apoptosis
Aspartate Aminotransferases - blood
Biomarkers
Biomedical research
Cadmium
Cadmium - toxicity
Catalase - metabolism
Depletion
Enzymes
Free radicals
Gene expression
Hepatotoxicity
Immunohistochemistry
Iridoids - pharmacology
Kidneys
L-Lactate Dehydrogenase - blood
Lipid peroxidation
Lipid Peroxidation - drug effects
Lipids
Liver
Liver - drug effects
Liver - metabolism
Male
Medical research
Medicine, Botanic
Medicine, Herbal
Mice
Olea - chemistry
Oleuropein
Oxidative stress
Peroxidation
Phosphatase
Plant extracts
Plant Extracts - pharmacology
Plant Leaves - chemistry
Pollutants
Polyphenols
Superoxide Dismutase - metabolism
Toxicity
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Summary:Cadmium (Cd) is a harmful pollutant which mainly affects the liver and kidney. In this work, we investigated the hepatoprotective effects of olive leaf extract based on oleuropein against hepatic cadmium toxicity in mice. Three groups of animals were used: the first one served as the control (C); the second one received intraperitoneal injection of cadmium 2 mg/kg b.w. (CD), administered five times during two weeks; and the third group received the same doses of Cd and simultaneously 16 mg/kg b.w. of oleuropein. Results showed that Cd induced a significant increase in liver injury biomarkers coupled with enhanced lipid peroxidation (MDA) and significant depletion of antioxidants (CAT and SOD). Histological and immunohistochemical analysis confirmed these findings. In fact, we observed a severe central lobular apoptosis and inflammation around central veins. Cotreatment with oleuropein significantly reduced the oxidative damage induced by cadmium. Our findings suggest that oleuropein could be used in the prevention of Cd hepatotoxicity.
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/4398924