Prevalence of human rhinovirus in children admitted to hospital with acute lower respiratory tract infections in Changsha, China

• Published in: Journal of medical virology 2014-11, Vol.86 (11), p.1983-1989
• Main Authors: Zeng, Sai-Zhen, Xiao, Ni-Guang, Xie, Zhi-Ping, Xie, Guang-Cheng, Zhong, Li-Li, Wang, Juan, Huang, Han, Zhang, Bing, Duan, Zhao-Jun
• Format: Article
• Language: English
• Subjects: acute lower respiratory tract infections; Adolescent; Child; Child, Preschool; Children & youth; China; China - epidemiology; Cluster Analysis; Coinfection - epidemiology; Coinfection - virology; Colds; Female; Genetic Variation; Genotype; Genotype & phenotype; Hospitals; Human rhinovirus; Humans; Infant; Infant, Newborn; Male; Molecular Epidemiology; Nasopharynx - virology; Phylogeny; Picornaviridae Infections - epidemiology; Picornaviridae Infections - pathology; Picornaviridae Infections - virology; Polymerase Chain Reaction; Prevalence; Respiratory syncytial virus; Respiratory Tract Infections - epidemiology; Respiratory Tract Infections - pathology; Respiratory Tract Infections - virology; Rhinovirus - isolation & purification; Seasons; Sequence Analysis, DNA; Viral infections; Viral Proteins - genetics; Virology
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.23861

Human rhinovirus (HRV) is a causative agent of acute respiratory tract infections. This study analyzed the prevalence and clinical characteristics of three HRV groups (HRV‐A, ‐B, and ‐C) among 1,165 children aged 14 years or younger who were hospitalized with acute lower respiratory tract infection in China. PCR or reverse transcription‐PCR was performed to detect 14 respiratory viruses in nasopharyngeal aspirates collected from September 2007 to August 2008 in Changsha, China. HRV was detected in 202 (17.3%) of the 1,165 children; 25.3% of the HRV‐positive children were 13–36 months of age (χ2 = 22.803, P = 0.000). HRV was detected year round and peaked between September and December. Fifty‐three percent of the HRV‐positive samples were also positive for other respiratory viruses; respiratory syncytial virus (RSV) was the most common secondary virus. Phylogenetic analysis using the VP4/VP2 region grouped the HRV‐positive strains as follows: 101 HRV‐A (50.0%), 21 HRV‐B (10.4%), and 80 HRV‐C (39.6%). HRV‐A infections occurred predominantly in spring and autumn, and the peak prevalence of HRV‐C was in early winter and late autumn. HRV‐B infections were less common in spring (χ2 = 31.914, P = 0.000). No significant difference in clinical severity or presentation was found between patients with HRV single infection and HRV co‐detections. Furthermore, the clinical characterizations did not differ among the three HRV species. These results suggest that HRV‐C is an important viral agent along with HRV‐A and HRV‐B and that among hospitalized children with acute lower respiratory tract infection in China, the three HRV genotypes have similar clinical characteristics. J. Med. Virol. 86:1983–1989, 2014. © 2014 Wiley Periodicals, Inc.