Different pattern of viral infections and clinical outcomes in patient with acute exacerbation of chronic obstructive pulmonary disease and chronic obstructive pulmonary disease with pneumonia

Respiratory viruses are well‐known causes of acute exacerbation of chronic obstructive pulmonary disease (AE‐COPD) and also important pathogens for concomitant pneumonia in COPD (CP‐COPD). However, the differences in a viral infection pattern and clinical impacts of respiratory viruses between the t...

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Bibliographic Details
Published in:Journal of medical virology 2016-12, Vol.88 (12), p.2092-2099
Main Authors: Kim, Ho-Cheol, Choi, Sang-Ho, Huh, Jin-Won, Sung, Heungsup, Hong, Sang Bum, Lim, Chae-Man, Koh, Younsuck
Format: Article
Language:English
Subjects:
Acute Disease
acute exacerbation
Aged
Aged, 80 and over
Bacterial Infections - complications
Chronic obstructive pulmonary disease
Clinical outcomes
Cohort Studies
Coinfection - complications
Coinfection - microbiology
Coinfection - virology
COPD
Coronaviridae
Disease Progression
Female
Hospitalization
Humans
Male
Middle Aged
Orthomyxoviridae
Orthomyxoviridae - isolation & purification
outcome
Pneumonia
Pneumonia - complications
Pulmonary Disease, Chronic Obstructive - complications
Pulmonary Disease, Chronic Obstructive - microbiology
Pulmonary Disease, Chronic Obstructive - mortality
Pulmonary Disease, Chronic Obstructive - virology
respiratory virus
Retrospective Studies
Viral infections
Virology
Virus Diseases - complications
Viruses - classification
Viruses - isolation & purification
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Summary:Respiratory viruses are well‐known causes of acute exacerbation of chronic obstructive pulmonary disease (AE‐COPD) and also important pathogens for concomitant pneumonia in COPD (CP‐COPD). However, the differences in a viral infection pattern and clinical impacts of respiratory viruses between the two groups have not been well investigated. The clinical and microbiological data from COPD patients admitted with AE‐COPD (n = 281) or CP‐COPD (n = 284) between January 2010 and December 2012 were reviewed. After excluding 88 patients (40 with AE‐COPD and 48 with CP‐COPD) who did not undergo a multiplex RT‐PCR test for respiratory viruses, the demographic characteristics, identified viruses, and clinical outcomes of the AE‐COPD and CP‐COPD groups were compared. Respiratory viruses were identified in 41.9% of AE‐COPD group and 33.5% of the CP‐COPD groups. The most common virus was influenza virus in the AE‐COPD group (33.7%) versus human coronavirus (24.1%) in the CP‐COPD group. Influenza virus was significantly more common in the AE‐ACOPD group than in the CP‐COPD group (P 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24577