Disseminated histoplasmosis in a cat in Europe

A cat was presented with a history of vomiting, decreased appetite and weight loss. Abnormal findings were poor body condition, pale mucous membranes, dehydration and a palpable abdominal mass. Abdominal ultrasound showed lymph node enlargement, a mass of uncertain origin, thickening of the muscular...

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Bibliographic Details
Published in:Journal of small animal practice 2010-03, Vol.51 (3), p.176-180
Main Authors: Mavropoulou, A, Grandi, G, Calvi, L, Passeri, B, Volta, A, Kramer, L.H, Quintavalla, C
Format: Article
Language:English
Subjects:
abdomen
animal pathogenic fungi
Animals
Appetite
body fluids
Case Reports
case studies
cat diseases
Cat Diseases - diagnosis
Cat Diseases - epidemiology
Cat Diseases - microbiology
Cats
Climate
Cytoplasm
Dehydration
disease course
Effusion
Europe - epidemiology
Fatal Outcome
Histoplasma capsulatum
Histoplasmosis
Histoplasmosis - diagnosis
Histoplasmosis - epidemiology
Histoplasmosis - veterinary
Ileum
Immunohistochemistry
Intestine
intestines
Lung nodules
lungs
Lymph nodes
Macrophages
Male
Nodules
Omentum
peritoneal fluid
signs and symptoms (animals and humans)
ultrasonography
Ultrasound
Vomiting
weight loss
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Description
Summary:A cat was presented with a history of vomiting, decreased appetite and weight loss. Abnormal findings were poor body condition, pale mucous membranes, dehydration and a palpable abdominal mass. Abdominal ultrasound showed lymph node enlargement, a mass of uncertain origin, thickening of the muscularis layer of the small bowel, focal thickening of the ileum with loss of layering and free peritoneal fluid. Cytology revealed a piogranulomatous infiltrate and numerous macrophages containing oval or round yeast-like cells 2 to 5 μm diameter with a central, spherical, lightly basophilic body surrounded by a clear halo, compatible with Histoplasma capsulatum, within the cytoplasm. Post-mortem examination revealed cavity effusions, granulomatous nodules in lungs, intestine and omentum, thickened intestinal walls and intestinal perforation. Staining with Grocott and immunohistochemistry (IHC) revealed numerous organisms within the granulomatous reaction. H. capsulatum has a worldwide distribution in temperate and subtropical climates. To the author's knowledge, this is the first report of feline histoplasmosis in Europe.
ISSN:0022-4510
1748-5827
DOI:10.1111/j.1748-5827.2010.00866.x