Pteropine orthoreovirus infection among out-patients with acute upper respiratory tract infection in Malaysia

This study aims to assess the incidence rate of Pteropine orthreovirus (PRV) infection in patients with acute upper respiratory tract infection (URTI) in a suburban setting in Malaysia, where bats are known to be present in the neighborhood. Using molecular detection of PRVs directly from oropharyng...

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Bibliographic Details
Published in:Journal of medical virology 2015-12, Vol.87 (12), p.2149-2153
Main Authors: Voon, Kenny, Tan, Yeh Fong, Leong, Pooi Pooi, Teng, Cheong Lieng, Gunnasekaran, Rajasekaran, Ujang, Kamsiah, Chua, Kaw Bing, Wang, Lin-Fa
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Capsid Proteins - genetics
Epidemiology
Female
Genotype
Humans
Incidence
Kampar virus
Malaysia - epidemiology
Male
Melaka virus
Middle Aged
Molecular Diagnostic Techniques
Nelson Bay virus
Oropharynx - virology
Orthoreovirus
Orthoreovirus - isolation & purification
Outpatients
Pathogenesis
Phylogenetics
Phylogeny
Pteropine orthoreovirus
Pulau virus
Reoviridae Infections - diagnosis
Reoviridae Infections - epidemiology
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - virology
Sequence Analysis, DNA
Short Communication
Short Communications
Suburban Population
Viral infections
Virology
Young Adult
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Summary:This study aims to assess the incidence rate of Pteropine orthreovirus (PRV) infection in patients with acute upper respiratory tract infection (URTI) in a suburban setting in Malaysia, where bats are known to be present in the neighborhood. Using molecular detection of PRVs directly from oropharyngeal swabs, our study demonstrates that PRV is among one of the common causative agents of acute URTI with cough and sore throat as the commonest presenting clinical features. Phylogenetic analysis on partial major outer and inner capsid proteins shows that these PRV strains are closely related to Melaka and Kampar viruses previously isolated in Malaysia. Further study is required to determine the public health significance of PRV infection in Southeast Asia, especially in cases where co‐infection with other pathogens may potentially lead to different clinical outcomes. J. Med. Virol. 87:2149–2153, 2015. © 2015 Wiley Periodicals, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24304