Effect of inapparent murine hepatitis virus infections on macrophages and host resistance

Inapparent infections of mice with murine hepatitis virus (MHV) altered host resistance to experimental infection with a second virus, encephalomyocarditis virus (EMC), reduced the protective effects of exogeneously administered interferon against EMC infections, and it altered macrophage ectoenzyme...

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Bibliographic Details
Published in:Journal of leukocyte biology 1986-05, Vol.39 (5), p.559-565
Main Authors: Dempsey, Walla L., Smith, Abigail L., Morahan, Page S.
Format: Article
Language:English
Subjects:
5'-Nucleotidase
Alkaline Phosphatase - metabolism
Animal viral diseases
Animals
Biological and medical sciences
Bone Marrow Cells
bone marrow derived macrophages
ectoenzymes
Encephalomyocarditis virus - immunology
Enterovirus Infections - immunology
Hepatitis, Viral, Animal - immunology
Immunity
Infectious diseases
Macrophages - enzymology
Macrophages - immunology
Medical sciences
Mice
mononuclear phagocytes
Murine hepatitis virus
Nucleotidases - metabolism
Phosphoric Diester Hydrolases - metabolism
Viral diseases
viral infections
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Summary:Inapparent infections of mice with murine hepatitis virus (MHV) altered host resistance to experimental infection with a second virus, encephalomyocarditis virus (EMC), reduced the protective effects of exogeneously administered interferon against EMC infections, and it altered macrophage ectoenzyme phenotypes in two macrophage populations. Resident peritoneal macrophages from mice experimentally infected with one of two strains of MHV also demonstrated altered ectoenzyme phenotypes. These data demonstrate that inapparent infections with MHV alter several host resistance and macrophage parameters and directly demonstrate that effects of inapparent MHV infection on macrophage parameters can be reproduced experimentally.
ISSN:0741-5400
1938-3673
DOI:10.1002/jlb.39.5.559