Transforming growth factor-beta 1 in humidifier disinfectant-associated children's interstitial lung disease

• Published in: Pediatric pulmonology 2016-02, Vol.51 (2), p.173-182
• Main Authors: Kim, Yoon Hee, Kim, Kyung Won, Lee, Kyung Eun, Lee, Mi-Jung, Kim, Sang Kyum, Kim, Se Hoon, Shim, Hyo Sup, Lee, Chang Young, Kim, Myung-Joon, Sohn, Myung Hyun, Kim, Kyu-Earn
• Format: Article
• Language: English
• Subjects: Cell Adhesion Molecules - immunology; Chemokine CCL2 - immunology; Chemokine CCL5 - immunology; child; Child, Preschool; Disinfectants - adverse effects; Female; Fibrosis; Granulocyte-Macrophage Colony-Stimulating Factor - immunology; Humans; Humidifiers; Infant; Inflammation; Interleukin-13 - immunology; Interleukin-8 - immunology; interstitial; Lung - diagnostic imaging; Lung - immunology; Lung - pathology; lung disease; Lung Diseases, Interstitial - chemically induced; Lung Diseases, Interstitial - immunology; Lung Diseases, Interstitial - mortality; Lung Injury - chemically induced; Lung Injury - immunology; Lung Injury - mortality; Male; Matrix Metalloproteinase 9 - immunology; Original; Prognosis; Tomography, X-Ray Computed; transforming growth factor beta1; Transforming Growth Factor beta1 - immunology; Vascular Endothelial Growth Factor A - immunology; wound healing
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.23226

Summary Background Humidifier disinfectant‐associated children's interstitial lung disease has an unpredictable clinical course with a high morbidity and mortality. Objectives To evaluate the differences in clinical findings between survivors and non‐survivors of humidifier disinfectant‐associated children's interstitial lung disease. To evaluate dynamic changes in serum cytokines related to inflammation and fibrosis in lung injury, and to determine whether these changes are predictive of survival in this disease. Methods We evaluated 17 children with humidifier disinfectant‐associated children's interstitial lung disease, from whom serum samples were obtained weekly during hospitalization. The severity of chest tomographic and lung pathologic findings was scored. Levels of several cytokines were measured in the serial serum samples. Results Seven of the 17 children were survivors. Compared to survivors, non‐survivors had greater ground‐glass attenuation on follow‐up chest tomography, higher admission neutrophil counts, and more macrophages on pathologic findings. Transforming growth factor‐beta 1 persisted at an elevated level (1,000–1,500 pg/ml) in survivors, whereas it decreased abruptly in non‐survivors. At the time of this decrease, non‐survivors had clinical worsening of their respiratory failure. Transforming growth factor‐beta 1 was positively correlated with PaO2/FiO2 (r = 0.481, P