Preoperative Mannan‐Binding Lectin Pathway and Prognosis in Colorectal Cancer

Background:  Deficiency of the mannan‐binding lectin (MBL) pathway of innate immunity leads to increased susceptibility to infections. In patients with colorectal cancer, postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate (1) the relation between...

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Published in:Scandinavian journal of immunology 2004-06, Vol.59 (6), p.636-636
Main Authors: Ytting, H., Christensen, I. J., Thiel, S., Jensenius, J. C., Nielsen, H. J.
Format: Article
Language:English
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Summary:Background:  Deficiency of the mannan‐binding lectin (MBL) pathway of innate immunity leads to increased susceptibility to infections. In patients with colorectal cancer, postoperative infection is associated with poor prognosis. The aim of the present study was to evaluate (1) the relation between the MBL pathway and postoperative infectious complications and survival of patients resected for colorectal cancer and (2) the role of MBL as acute phase reactant compared to CRP. Methods:  Preoperative MBL concentration, MBL/MBL‐associated serine protease (MASP) activity and CRP were determined in serum from 611 patients and 150 healthy controls. The patients were observed for 8 years. Postoperative infections, recurrence and survival were recorded. Results:  The MBL pathway components were increased in the patients (P 
ISSN:0300-9475
1365-3083
DOI:10.1111/j.0300-9475.2004.01423bn.x