MiR‐210‐3p‐EphrinA3‐PI3K/AKT axis regulates the progression of oral cancer

This study aimed to explore new therapeutic targets to improve the survival rate of patients with oral squamous cell carcinoma (OSCC).MiR‐210‐3p, EphrinA3 and EMT related indices were evaluated in OSCC tissues and cell lines. In addition, the relationship between differential EphrinA3 expression and...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2020-04, Vol.24 (7), p.4011-4022
Main Authors: Wang, Lin, Song, Yong, Wang, Hui, Liu, Ke, Shao, Zhe, Shang, Zhengjun
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
Aged
AKT protein
Animals
cancer biology
Carcinogenesis - genetics
Cell growth
Cell Line, Tumor
Cell Proliferation - genetics
cell signalling
Disease Progression
Disease-Free Survival
Ephrin-A3 - genetics
epithelial‐mesenchymal interactions
Ethics
Female
gene expression
Gene Expression Regulation, Neoplastic - genetics
gene therapy/therapeutics
Growth factors
Heterografts
Histology
Humans
Hypoxia
Immunoglobulins
Kinases
Laboratory animals
Ligands
Male
Mice
MicroRNAs - genetics
Middle Aged
Oral cancer
oral carcinogenesis
Oral squamous cell carcinoma
Original
Phosphatidylinositol 3-Kinases - genetics
Proteins
Proto-Oncogene Proteins c-akt - genetics
Signal Transduction
Squamous cell carcinoma
Squamous Cell Carcinoma of Head and Neck - genetics
Squamous Cell Carcinoma of Head and Neck - pathology
Therapeutic applications
Tumors
Xenografts
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Summary:This study aimed to explore new therapeutic targets to improve the survival rate of patients with oral squamous cell carcinoma (OSCC).MiR‐210‐3p, EphrinA3 and EMT related indices were evaluated in OSCC tissues and cell lines. In addition, the relationship between differential EphrinA3 expression and tumour progression was explored through molecular biology techniques, in vitro functional experiments and tumour xenotransplantation models. The expression of EphrinA3 (rs = −0.719, P 
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.15036