Efficacy of Curcumin with Iontophoretic Application on Paw Edema and Hematological Responses in Collagen-Induced Arthritis Rat Models

Background. According to previous studies, oral administration of curcumin elucidates anti-inflammatory effect irrespective of its poor bioavailability. This study aims to measure the efficacy of lyophilized curcumin extracts with iontophoresis in arthritic rat models. Methods. Lyophilization and ch...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-11
Main Authors: Alghadir, Ahmad, Ali, Sharique, Miraj, Mohammad
Format: Article
Language:English
Subjects:
Animal models
Arthritis
Bioavailability
Body weight
Cartilage
Chromatography
Collagen
Curcumin
Dropsy
Drug dosages
Edema
Erythrocyte sedimentation rate
Freeze drying
Geriatrics
Hematology
Inflammation
Iontophoresis
Methods
Nonsteroidal anti-inflammatory drugs
Oral administration
Pharmaceuticals
Rheumatoid arthritis
Topical application
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Summary:Background. According to previous studies, oral administration of curcumin elucidates anti-inflammatory effect irrespective of its poor bioavailability. This study aims to measure the efficacy of lyophilized curcumin extracts with iontophoresis in arthritic rat models. Methods. Lyophilization and characterization of curcumin using the standard HPTLC method was carried out followed by induction of inflammatory arthritis in male albino rats. The animals were then treated with curcumin in three different forms, i.e., oral curcumin (OCU), oral curcumin with topical application (OCU + TOCU), and oral curcumin along with iontophoretically applied curcumin (OCU + IOCU). Various objective variables including body weight, paw edema, arthritic scores, and hematological and biochemical parameters, as well as histopathological examinations were conducted. Results. All the curcumin-treated groups showed significant alleviation of arthritic condition (p∗
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/4606520