Enteroviruses as major cause of microbiologically unexplained acute respiratory tract infections in hospitalized pediatric patients

Summary Objective To assess the etiological role and the clinical characteristics of HRV and HEV infections in pediatric patients hospitalized for acute respiratory tract infections (ARTIs). Methods RT-qPCR assays and molecular sequencing methods were used to identify HRV and HEV strains in nasophar...

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Bibliographic Details
Published in:The Journal of infection 2013-06, Vol.66 (6), p.494-502
Main Authors: Renois, Fanny, Lévêque, Nicolas, Deliège, Pierre-Guillaume, Fichel, Caroline, Bouin, Alexis, Abely, Michel, N'Guyen, Yohan, Andréoletti, Laurent
Format: Article
Language:English
Subjects:
Acute Disease
Biological and medical sciences
Bronchiolitis
Bronchiolitis - epidemiology
Bronchiolitis - virology
Child
Child, Preschool
Clinical severity
Enterovirus - classification
Enterovirus - genetics
Enterovirus - isolation & purification
Enterovirus genus
Epidemiology
Female
France - epidemiology
General aspects
Hepatitis E virus
Hospitalization - statistics & numerical data
Human health and pathology
Humans
Infant
Infectious Disease
Infectious diseases
Life Sciences
Male
Medical sciences
Nasopharynx - virology
Pediatric patients
Pediatrics
Phylogeny
Picornaviridae Infections - epidemiology
Picornaviridae Infections - virology
Pulmonology and respiratory tract
Real-Time Polymerase Chain Reaction
Respiratory Tract Infections - epidemiology
Respiratory Tract Infections - virology
Retrospective Studies
Rhinovirus
Rhinovirus - classification
Rhinovirus - genetics
Rhinovirus - isolation & purification
RT-qPCR assay
Wheezing
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Summary:Summary Objective To assess the etiological role and the clinical characteristics of HRV and HEV infections in pediatric patients hospitalized for acute respiratory tract infections (ARTIs). Methods RT-qPCR assays and molecular sequencing methods were used to identify HRV and HEV strains in nasopharyngeal aspirates of 309 hospitalized pediatric patients with microbiologically unexplained ARTIs and in 210 hospitalized pediatric patients without respiratory symptoms from September 2009 to June 2010 in France. Results Among the 309 ARTI cases, 15 HEV and 172 HRV strains were identified whereas only 1 HEV and 37 HRV strains were observed in control patients (187 vs. 38: P  
ISSN:0163-4453
1532-2742
DOI:10.1016/j.jinf.2013.03.007