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The bacterial lysate Lantigen B reduces the number of acute episodes in patients with recurrent infections of the respiratory tract: The results of a double blind, placebo controlled, multicenter clinical trial
Highlights • Old trials on LantigenB (LB) showed its effect on recurrent respiratory infections. • These studies were performed using non-updated clinical and statistical methods. • Here we show that LB reduces the number of infections in a phase IV clinical study. • LB represents a real first-line...
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| Published in: | Immunology letters 2014-12, Vol.162 (2), p.185-193 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c617t-893856f0a92747b6d80726c3430c4662ca28882bdc62830349b24660f06526be3 |
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| container_end_page | 193 |
| container_issue | 2 |
| container_start_page | 185 |
| container_title | Immunology letters |
| container_volume | 162 |
| creator | Braido, Fulvio Melioli, Giovanni Candoli, Piero Cavalot, Andrea Di Gioacchino, Mario Ferrero, Vittorio Incorvaia, Cristoforo Mereu, Carlo Ridolo, Erminia Rolla, Giovanni Rossi, Oliviero Savi, Eleonora Tubino, Libero Reggiardo, Giorgio Baiardini, Ilaria di Marco, Eddi Rinaldi, Gilberto Canonica, Giorgio Walter Accorsi, Carlo Bossilino, Claudia Bonzano, Laura DiLizia, Michela Fedrighini, Barbara Garelli, Valentina Gerace, Vincenzo Maniscalco, Sara Massaro, Ilaria Messi, Alessandro Milanese, Manlio Peveri, Silvia Penno, Arminio Pizzimenti, Stefano Pozzo, Tiziana Raie, Alberto Regina, Sergio Sclifò, Francesca |
| description | Highlights • Old trials on LantigenB (LB) showed its effect on recurrent respiratory infections. • These studies were performed using non-updated clinical and statistical methods. • Here we show that LB reduces the number of infections in a phase IV clinical study. • LB represents a real first-line prophylaxis of recurrent respiratory infections. |
| doi_str_mv | 10.1016/j.imlet.2014.10.026 |
| format | article |
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All rights reserved.</rights><rights>2014 The Authors 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c617t-893856f0a92747b6d80726c3430c4662ca28882bdc62830349b24660f06526be3</citedby><cites>FETCH-LOGICAL-c617t-893856f0a92747b6d80726c3430c4662ca28882bdc62830349b24660f06526be3</cites><orcidid>0000-0003-0499-6311</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25445613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braido, Fulvio</creatorcontrib><creatorcontrib>Melioli, Giovanni</creatorcontrib><creatorcontrib>Candoli, Piero</creatorcontrib><creatorcontrib>Cavalot, Andrea</creatorcontrib><creatorcontrib>Di Gioacchino, Mario</creatorcontrib><creatorcontrib>Ferrero, Vittorio</creatorcontrib><creatorcontrib>Incorvaia, Cristoforo</creatorcontrib><creatorcontrib>Mereu, Carlo</creatorcontrib><creatorcontrib>Ridolo, Erminia</creatorcontrib><creatorcontrib>Rolla, Giovanni</creatorcontrib><creatorcontrib>Rossi, Oliviero</creatorcontrib><creatorcontrib>Savi, Eleonora</creatorcontrib><creatorcontrib>Tubino, Libero</creatorcontrib><creatorcontrib>Reggiardo, Giorgio</creatorcontrib><creatorcontrib>Baiardini, Ilaria</creatorcontrib><creatorcontrib>di Marco, Eddi</creatorcontrib><creatorcontrib>Rinaldi, Gilberto</creatorcontrib><creatorcontrib>Canonica, Giorgio Walter</creatorcontrib><creatorcontrib>Accorsi, Carlo</creatorcontrib><creatorcontrib>Bossilino, Claudia</creatorcontrib><creatorcontrib>Bonzano, Laura</creatorcontrib><creatorcontrib>DiLizia, Michela</creatorcontrib><creatorcontrib>Fedrighini, Barbara</creatorcontrib><creatorcontrib>Garelli, Valentina</creatorcontrib><creatorcontrib>Gerace, Vincenzo</creatorcontrib><creatorcontrib>Maniscalco, Sara</creatorcontrib><creatorcontrib>Massaro, Ilaria</creatorcontrib><creatorcontrib>Messi, Alessandro</creatorcontrib><creatorcontrib>Milanese, Manlio</creatorcontrib><creatorcontrib>Peveri, Silvia</creatorcontrib><creatorcontrib>Penno, Arminio</creatorcontrib><creatorcontrib>Pizzimenti, Stefano</creatorcontrib><creatorcontrib>Pozzo, Tiziana</creatorcontrib><creatorcontrib>Raie, Alberto</creatorcontrib><creatorcontrib>Regina, Sergio</creatorcontrib><creatorcontrib>Sclifò, Francesca</creatorcontrib><creatorcontrib>Lantigen Study Group</creatorcontrib><title>The bacterial lysate Lantigen B reduces the number of acute episodes in patients with recurrent infections of the respiratory tract: The results of a double blind, placebo controlled, multicenter clinical trial</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>Highlights • Old trials on LantigenB (LB) showed its effect on recurrent respiratory infections. • These studies were performed using non-updated clinical and statistical methods. • Here we show that LB reduces the number of infections in a phase IV clinical study. • LB represents a real first-line prophylaxis of recurrent respiratory infections.</description><subject>Acute Disease</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Allergy</subject><subject>Allergy and Immunology</subject><subject>Antigens, Bacterial - 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| identifier | ISSN: 0165-2478 |
| ispartof | Immunology letters, 2014-12, Vol.162 (2), p.185-193 |
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| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Acute Disease Adolescent Adult Aged Allergy Allergy and Immunology Antigens, Bacterial - administration & dosage Asthma - drug therapy Bacteria Bacterial lysates Double-Blind Method Female Follow-Up Studies History, Ancient Humans Immune-stimulant drugs Longitudinal Studies Male Middle Aged Prophylactic treatment Prospective Studies Recurrent respiratory tract infections Respiratory Tract Infections - drug therapy Severity of Illness Index |
| title | The bacterial lysate Lantigen B reduces the number of acute episodes in patients with recurrent infections of the respiratory tract: The results of a double blind, placebo controlled, multicenter clinical trial |
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