Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomics

Efflux pumps play a major role in the increasing antimicrobial resistance rendering a large number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant due to inadequate dosage and use of the existing antimicrobials. This leads to the need for identifying new efflux pump i...

Full description

Saved in:
Bibliographic Details
Published in:Progress in biophysics and molecular biology 2019-01, Vol.141, p.15-24
Main Authors: Kabra, Ritika, Chauhan, Nutan, Kumar, Anurag, Ingale, Prajakta, Singh, Shailza
Format: Article
Language:English
Subjects:
Anti-Infective Agents - pharmacology
Antimicrobial peptides
ATP binding cassette
Drug resistance
Drug Resistance - genetics
Efflux pumps
Genomics
Inflammation
Systems biology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Efflux pumps play a major role in the increasing antimicrobial resistance rendering a large number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant due to inadequate dosage and use of the existing antimicrobials. This leads to the need for identifying new efflux pump inhibitors. Design of novel targeted therapies using inherent complexity involved in the biological network modeling has gained increasing importance in recent times. The predictive approaches should be used to determine antimicrobial activities with high pathogen specificity and microbicidal potency. Antimicrobial peptides, which are part of our innate immune system, have the ability to respond to infections and have gained much attention in making resistant strain sensitive to existing drugs. In this review paper, we outline evidences linking host-directed therapy with the efflux pump activity to infectious disease.
ISSN:0079-6107
1873-1732
DOI:10.1016/j.pbiomolbio.2018.07.008