IL-1 and related cytokines in innate and adaptive immunity in health and disease

Forty years after its naming, IL-1 and related cytokines experience a renaissance as central mediators of inflammation and immunity. IL-1 family members, including IL-18, IL-33, IL-36, IL-37, and IL-38, play a key role in the orchestration of the diversity and plasticity of innate and adaptive immun...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2019-04, Vol.50 (4), p.778-795
Main Authors: Mantovani, Alberto, Dinarello, Charles A., Molgora, Martina, Garlanda, Cecilia
Format: Article
Language:English
Online Access:Get full text
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Summary:Forty years after its naming, IL-1 and related cytokines experience a renaissance as central mediators of inflammation and immunity. IL-1 family members, including IL-18, IL-33, IL-36, IL-37, and IL-38, play a key role in the orchestration of the diversity and plasticity of innate and adaptive immune responses. As such, these molecules are involved in homeostasis and in a range of pathologies, ranging from autoimmunity and autoinflammation, to dysmetabolism and cardiovascular disorders, to cancer. Dissection of the complexity and role in immunopathology of the IL-1 family has paved the way to development of trans-disease therapeutic strategies. Therefore, IL-1 serves as a paradigm for immunity and inflammation representing a metanarrative of modern medicine.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2019.03.012