The association between uric acid levels and renal function of CKD patients with hyperlipidemia: a sub-analysis of the ASUCA trial

Background The influence of uric acid (UA) on renal function and the significance of UA-lowering therapy are unclear. The purpose of the sub-analysis of the Assessment of Clinical Usefulness in chronic kidney disease patients with Atorvastatin (ASUCA) trial was to evaluate the influence of serum UA...

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Published in:Clinical and experimental nephrology 2020-05, Vol.24 (5), p.420-426
Main Authors: Kuwabara, Yoshihiro, Yasuno, Shinji, Kasahara, Masato, Ueshima, Kenji, Nakao, Kazuwa
Format: Article
Language:English
Subjects:
Aged
Anticholesteremic Agents - therapeutic use
Atorvastatin
Atorvastatin - therapeutic use
Disease Progression
Dyslipidemia
Epidermal growth factor receptors
Female
Glomerular Filtration Rate
Humans
Hyperlipidemia
Hyperlipidemias - complications
Hyperlipidemias - drug therapy
Hyperuricemia
Japan
Kidney diseases
Male
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Original
Original Article
Renal function
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
Risk Factors
Uric acid
Uric Acid - blood
Urology
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Summary:Background The influence of uric acid (UA) on renal function and the significance of UA-lowering therapy are unclear. The purpose of the sub-analysis of the Assessment of Clinical Usefulness in chronic kidney disease patients with Atorvastatin (ASUCA) trial was to evaluate the influence of serum UA levels on renal function in Japanese chronic kidney disease patients with hyperlipidemia. Methods Of 344 participants in the ASUCA trial, 279 participants whose UA levels at both baseline and 24 months were available were included. Based on UA level at baseline or mean UA level during the trial period, they were divided into four groups: 
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-019-01840-4