Epigenetic mechanism of SETDB1 in brain: implications for neuropsychiatric disorders

Neuropsychiatric disorders are a collective of cerebral conditions with a multifactorial and polygenetic etiology. Dysregulation of epigenetic profiles in the brain is considered to play a critical role in the development of neuropsychiatric disorders. SET domain, bifurcate 1 (SETDB1), functioning a...

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Bibliographic Details
Published in:Translational psychiatry 2020-04, Vol.10 (1), p.115-115, Article 115
Main Authors: Zhu, Yueyan, Sun, Daijing, Jakovcevski, Mira, Jiang, Yan
Format: Article
Language:English
Subjects:
45/91
631/378/2584
631/378/340
Behavioral Sciences
Biological Psychology
Epigenetics
Genomes
Medicine
Medicine & Public Health
Neurosciences
Pharmacotherapy
Psychiatry
Review
Review Article
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Summary:Neuropsychiatric disorders are a collective of cerebral conditions with a multifactorial and polygenetic etiology. Dysregulation of epigenetic profiles in the brain is considered to play a critical role in the development of neuropsychiatric disorders. SET domain, bifurcate 1 (SETDB1), functioning as a histone H3K9 specific methyltransferase, is not only critically involved in transcriptional silencing and local heterochromatin formation, but also affects genome-wide neuronal epigenetic profiles and is essential for 3D genome integrity. Here, we provide a review of recent advances towards understanding the role of SETDB1 in the central nervous system during early neurodevelopment as well as in the adult brain, with a particular focus on studies that link its functions to neuropsychiatric disorders and related behavioral changes, and the exploration of novel therapeutic strategies targeting SETDB1.
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-020-0797-7