Detection of Nicotine and Nicotine Metabolites in Units of Banked Blood

Abstract Objectives To determine the concentrations of nicotine and nicotine metabolites in RBC units as a means to estimate the point prevalence of exposure within the healthy donor pool. Methods Segments from 105 RBC units were tested for the presence of nicotine, cotinine, or trans-3ʹ-hydroxycoti...

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Bibliographic Details
Published in:American journal of clinical pathology 2019-04, Vol.151 (5), p.516-521
Main Authors: Wiencek, Joesph R, Gehrie, Eric A, Keiser, Amaris M, Szklarski, Penny C, Johnson-Davis, Kamisha L, Booth, Garrett S
Format: Article
Language:English
Subjects:
Blood Banks
Blood products
Chromatography, Liquid
Composition
Cotinine
Cotinine - analogs & derivatives
Cotinine - blood
Erythrocytes
Health aspects
Humans
Liquid chromatography
Mass spectroscopy
Metabolites
Neonates
Nicotine
Nicotine - blood
Original
Tandem Mass Spectrometry
Testing
Tobacco
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Summary:Abstract Objectives To determine the concentrations of nicotine and nicotine metabolites in RBC units as a means to estimate the point prevalence of exposure within the healthy donor pool. Methods Segments from 105 RBC units were tested for the presence of nicotine, cotinine, or trans-3ʹ-hydroxycotinine by liquid chromatography–tandem mass spectrometry. Results Of the 20 (19%) units that contained detectable concentrations of nicotine, cotinine, or trans-3ʹ-hydroxycotinine, 19 (18.1%) contained concentrations consistent with the use of a nicotine-containing product within 48 hours of specimen collection. One RBC unit contained nicotine concentrations consistent with passive exposure. Conclusions Chemicals from nicotine-containing products are detectable within the US RBC supply. Further investigation is needed to determine the risks of transfusion-associated exposure to nicotine and other tobacco-associated chemicals among vulnerable patient populations such as neonates.
ISSN:0002-9173
1943-7722
DOI:10.1093/ajcp/aqy176