Upper and Lower Extremity Measurement of Tissue Sodium and Fat Content in Patients with Lipedema

Objective The aim of this study is to compare tissue sodium and fat content in the upper and lower extremities of participants with lipedema versus controls using magnetic resonance imaging (MRI). Methods MRI was performed at 3.0 T in females with lipedema (n = 15, age = 43.2 ± 10.0 years, BMI = 30....

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Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2020-05, Vol.28 (5), p.907-915
Main Authors: Crescenzi, Rachelle, Donahue, Paula M.C., Petersen, Kalen J., Garza, Maria, Patel, Niral, Lee, Chelsea, Beckman, Joshua A., Donahue, Manus J.
Format: Article
Language:English
Subjects:
Age
Body fat
Connective tissue diseases
Edema
Gastrointestinal surgery
Hypotheses
Legs
Magnetic resonance imaging
Obesity
Pain
Skin
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Summary:Objective The aim of this study is to compare tissue sodium and fat content in the upper and lower extremities of participants with lipedema versus controls using magnetic resonance imaging (MRI). Methods MRI was performed at 3.0 T in females with lipedema (n = 15, age = 43.2 ± 10.0 years, BMI = 30.3 ± 4.4 kg/m2) and controls without lipedema (n = 14, age = 42.8 ± 13.2 years, BMI = 28.8 ± 4.4 kg/m2). Participants were assessed for pain and disease stage. Sodium MRI was performed in the forearm and calf to quantify regional tissue sodium content (TSC, mmol/L). Chemical‐shift–encoded water‐fat MRI was performed in identical regions for measurement of fat/water (ratio). Results In the calf, skin TSC (16.3 ± 2.6 vs. 14.4 ± 2.2 mmol/L, P = 0.04), muscle TSC (20.3 ± 3.0 vs. 18.3 ± 1.7 mmol/L, P = 0.03), and fat/water (1.03 ± 0.37 vs. 0.56 ± 0.21 ratio, P 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.22778