Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men

Abstract Context Glucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon rece...

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Published in:The journal of clinical endocrinology and metabolism 2020-06, Vol.105 (6), p.1899-1905
Main Authors: Izzi-Engbeaya, Chioma, Jones, Sophie, Crustna, Yoshibye, Machenahalli, Pratibha C, Papadopoulou, Deborah, Modi, Manish, Starikova, Jessica, Chan, Derek, Eng, Pei Chia, Phylactou, Maria, Ratnasabapathy, Risheka, Mills, Edouard, Yang, Lisa, Pacuszka, Ewa, Bech, Paul, Minnion, James, Tharakan, George, Tan, Tricia, Veldhuis, Johannes, Abbara, Ali, Comninos, Alexander N, Dhillo, Waljit S
Format: Article
Language:English
Subjects:
Acute effects
Adult
Biological control systems
Biomarkers - metabolism
Body mass index
Body weight gain
Clinical s
Cross-Over Studies
Energy expenditure
Follicle Stimulating Hormone - metabolism
Follicle-stimulating hormone
Gastrointestinal Agents - administration & dosage
Glucagon
Glucagon - administration & dosage
Health aspects
Hormones
Humans
Hypogonadism
Insulin
Intravenous administration
Luteinizing hormone
Luteinizing Hormone - drug effects
Luteinizing Hormone - metabolism
Male
Obesity
Prognosis
Properties
Reproduction
Secretion
Single-Blind Method
Testosterone
Testosterone - metabolism
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Summary:Abstract Context Glucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon receptor agonism on reproductive hormones is important for developing therapeutics for obesity; but reports in the literature about the effects of glucagon receptor agonism on the reproductive axis are conflicting. Objective The objective of this work is to investigate the effect of glucagon administration on reproductive hormone secretion in healthy young men. Design A single-blinded, randomized, placebo-controlled crossover study was conducted. Setting The setting of this study was the Clinical Research Facility, Imperial College Healthcare NHS Trust. Participants Eighteen healthy eugonadal men (mean ± SEM: age 25.1 ± 1.0 years; body mass index 22.5 ± 0.4 kg/m2; testosterone 21.2 ± 1.2 nmol/L) participated in this study. Intervention An 8-hour intravenous infusion of 2 pmol/kg/min glucagon or rate-matched vehicle infusion was administered. Main Outcome Measures Luteinizing hormone (LH) pulsatility; LH, follicle-stimulating hormone (FSH), and testosterone levels were measured. Results Although glucagon administration induced metabolic effects (insulin area under the curve: vehicle 1065 ± 292 min.µU/mL vs glucagon 2098 ± 358 min.µU/mL, P 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgaa164