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Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men
Abstract Context Glucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon rece...
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| Published in: | The journal of clinical endocrinology and metabolism 2020-06, Vol.105 (6), p.1899-1905 |
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| container_end_page | 1905 |
| container_issue | 6 |
| container_start_page | 1899 |
| container_title | The journal of clinical endocrinology and metabolism |
| container_volume | 105 |
| creator | Izzi-Engbeaya, Chioma Jones, Sophie Crustna, Yoshibye Machenahalli, Pratibha C Papadopoulou, Deborah Modi, Manish Starikova, Jessica Chan, Derek Eng, Pei Chia Phylactou, Maria Ratnasabapathy, Risheka Mills, Edouard Yang, Lisa Pacuszka, Ewa Bech, Paul Minnion, James Tharakan, George Tan, Tricia Veldhuis, Johannes Abbara, Ali Comninos, Alexander N Dhillo, Waljit S |
| description | Abstract
Context
Glucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon receptor agonism on reproductive hormones is important for developing therapeutics for obesity; but reports in the literature about the effects of glucagon receptor agonism on the reproductive axis are conflicting.
Objective
The objective of this work is to investigate the effect of glucagon administration on reproductive hormone secretion in healthy young men.
Design
A single-blinded, randomized, placebo-controlled crossover study was conducted.
Setting
The setting of this study was the Clinical Research Facility, Imperial College Healthcare NHS Trust.
Participants
Eighteen healthy eugonadal men (mean ± SEM: age 25.1 ± 1.0 years; body mass index 22.5 ± 0.4 kg/m2; testosterone 21.2 ± 1.2 nmol/L) participated in this study.
Intervention
An 8-hour intravenous infusion of 2 pmol/kg/min glucagon or rate-matched vehicle infusion was administered.
Main Outcome Measures
Luteinizing hormone (LH) pulsatility; LH, follicle-stimulating hormone (FSH), and testosterone levels were measured.
Results
Although glucagon administration induced metabolic effects (insulin area under the curve: vehicle 1065 ± 292 min.µU/mL vs glucagon 2098 ± 358 min.µU/mL, P |
| doi_str_mv | 10.1210/clinem/dgaa164 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7182124</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A639890247</galeid><oup_id>10.1210/clinem/dgaa164</oup_id><sourcerecordid>A639890247</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5624-708c03e2396955996006c790ef39d9308883da45093ca69112963e6e2d9308043</originalsourceid><addsrcrecordid>eNqFkdtrFDEUxoModq2--igDvujDtieXyUxehKXUrlIRvIBvIWbO7KZmkjWZael_b7a71gsVSSCQ73e-5JyPkKcUjiijcGy9CzgcdytjqBT3yIwqUc8bqpr7ZAbA6Fw17MsBeZTzBQAVouYPyQFnjDMu-Yy8XdhpxOq079GOuYp9deYna1YxVGV_wE2K3WRHd4nVMqYhBqw-ok04uiK7UC3R-HF9Xb3D8Jg86I3P-GR_HpLPr08_nSzn5-_P3pwszue2lkzMG2gtcGRcSVXXSkkAaRsF2HPVKQ5t2_LOiBoUt0YqSpmSHCWyGxEEPySvdr6b6euAncUwJuP1JrnBpGsdjdN_KsGt9Spe6oa2jLKtwYu9QYrfJ8yjHly26L0JGKesGW9r1lBgdUGf_4VexCmF0p5mAmoupGjgF7UyHrULfSzv2q2pXkiuWgVMNIU6uoMqq8PB2TLZ3pX7uwpsijkn7G97pKC36etd-nqffil49vtkbvGfcReA7YCr6EdM-ZufrjDp9U2I_3Z9uSuK0-Z_P_gBwkvJJA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2405346470</pqid></control><display><type>article</type><title>Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men</title><source>Oxford Journals Online</source><creator>Izzi-Engbeaya, Chioma ; Jones, Sophie ; Crustna, Yoshibye ; Machenahalli, Pratibha C ; Papadopoulou, Deborah ; Modi, Manish ; Starikova, Jessica ; Chan, Derek ; Eng, Pei Chia ; Phylactou, Maria ; Ratnasabapathy, Risheka ; Mills, Edouard ; Yang, Lisa ; Pacuszka, Ewa ; Bech, Paul ; Minnion, James ; Tharakan, George ; Tan, Tricia ; Veldhuis, Johannes ; Abbara, Ali ; Comninos, Alexander N ; Dhillo, Waljit S</creator><creatorcontrib>Izzi-Engbeaya, Chioma ; Jones, Sophie ; Crustna, Yoshibye ; Machenahalli, Pratibha C ; Papadopoulou, Deborah ; Modi, Manish ; Starikova, Jessica ; Chan, Derek ; Eng, Pei Chia ; Phylactou, Maria ; Ratnasabapathy, Risheka ; Mills, Edouard ; Yang, Lisa ; Pacuszka, Ewa ; Bech, Paul ; Minnion, James ; Tharakan, George ; Tan, Tricia ; Veldhuis, Johannes ; Abbara, Ali ; Comninos, Alexander N ; Dhillo, Waljit S</creatorcontrib><description>Abstract
Context
Glucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon receptor agonism on reproductive hormones is important for developing therapeutics for obesity; but reports in the literature about the effects of glucagon receptor agonism on the reproductive axis are conflicting.
Objective
The objective of this work is to investigate the effect of glucagon administration on reproductive hormone secretion in healthy young men.
Design
A single-blinded, randomized, placebo-controlled crossover study was conducted.
Setting
The setting of this study was the Clinical Research Facility, Imperial College Healthcare NHS Trust.
Participants
Eighteen healthy eugonadal men (mean ± SEM: age 25.1 ± 1.0 years; body mass index 22.5 ± 0.4 kg/m2; testosterone 21.2 ± 1.2 nmol/L) participated in this study.
Intervention
An 8-hour intravenous infusion of 2 pmol/kg/min glucagon or rate-matched vehicle infusion was administered.
Main Outcome Measures
Luteinizing hormone (LH) pulsatility; LH, follicle-stimulating hormone (FSH), and testosterone levels were measured.
Results
Although glucagon administration induced metabolic effects (insulin area under the curve: vehicle 1065 ± 292 min.µU/mL vs glucagon 2098 ± 358 min.µU/mL, P < .001), it did not affect LH pulsatility (number of LH pulses/500 min: vehicle 4.7 ± 0.4, glucagon 4.2 ± 0.4, P = .22). Additionally, there were no significant differences in circulating LH, FSH, or testosterone levels during glucagon administration compared with vehicle administration.
Conclusions
Acute administration of a metabolically active dose of glucagon does not alter reproductive hormone secretion in healthy men. These data are important for the continued development of glucagon-based treatments for obesity.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/clinem/dgaa164</identifier><identifier>PMID: 32232363</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Acute effects ; Adult ; Biological control systems ; Biomarkers - metabolism ; Body mass index ; Body weight gain ; Clinical s ; Cross-Over Studies ; Energy expenditure ; Follicle Stimulating Hormone - metabolism ; Follicle-stimulating hormone ; Gastrointestinal Agents - administration & dosage ; Glucagon ; Glucagon - administration & dosage ; Health aspects ; Hormones ; Humans ; Hypogonadism ; Insulin ; Intravenous administration ; Luteinizing hormone ; Luteinizing Hormone - drug effects ; Luteinizing Hormone - metabolism ; Male ; Obesity ; Prognosis ; Properties ; Reproduction ; Secretion ; Single-Blind Method ; Testosterone ; Testosterone - metabolism</subject><ispartof>The journal of clinical endocrinology and metabolism, 2020-06, Vol.105 (6), p.1899-1905</ispartof><rights>Endocrine Society 2020. 2020</rights><rights>Copyright © Oxford University Press 2015</rights><rights>Endocrine Society 2020.</rights><rights>COPYRIGHT 2020 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5624-708c03e2396955996006c790ef39d9308883da45093ca69112963e6e2d9308043</citedby><cites>FETCH-LOGICAL-c5624-708c03e2396955996006c790ef39d9308883da45093ca69112963e6e2d9308043</cites><orcidid>0000-0003-2795-5256 ; 0000-0001-5950-4316 ; 0000-0001-7599-0166 ; 0000-0001-5873-3432 ; 0000-0002-4987-1224 ; 0000-0002-7104-2297</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32232363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Izzi-Engbeaya, Chioma</creatorcontrib><creatorcontrib>Jones, Sophie</creatorcontrib><creatorcontrib>Crustna, Yoshibye</creatorcontrib><creatorcontrib>Machenahalli, Pratibha C</creatorcontrib><creatorcontrib>Papadopoulou, Deborah</creatorcontrib><creatorcontrib>Modi, Manish</creatorcontrib><creatorcontrib>Starikova, Jessica</creatorcontrib><creatorcontrib>Chan, Derek</creatorcontrib><creatorcontrib>Eng, Pei Chia</creatorcontrib><creatorcontrib>Phylactou, Maria</creatorcontrib><creatorcontrib>Ratnasabapathy, Risheka</creatorcontrib><creatorcontrib>Mills, Edouard</creatorcontrib><creatorcontrib>Yang, Lisa</creatorcontrib><creatorcontrib>Pacuszka, Ewa</creatorcontrib><creatorcontrib>Bech, Paul</creatorcontrib><creatorcontrib>Minnion, James</creatorcontrib><creatorcontrib>Tharakan, George</creatorcontrib><creatorcontrib>Tan, Tricia</creatorcontrib><creatorcontrib>Veldhuis, Johannes</creatorcontrib><creatorcontrib>Abbara, Ali</creatorcontrib><creatorcontrib>Comninos, Alexander N</creatorcontrib><creatorcontrib>Dhillo, Waljit S</creatorcontrib><title>Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Context
Glucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon receptor agonism on reproductive hormones is important for developing therapeutics for obesity; but reports in the literature about the effects of glucagon receptor agonism on the reproductive axis are conflicting.
Objective
The objective of this work is to investigate the effect of glucagon administration on reproductive hormone secretion in healthy young men.
Design
A single-blinded, randomized, placebo-controlled crossover study was conducted.
Setting
The setting of this study was the Clinical Research Facility, Imperial College Healthcare NHS Trust.
Participants
Eighteen healthy eugonadal men (mean ± SEM: age 25.1 ± 1.0 years; body mass index 22.5 ± 0.4 kg/m2; testosterone 21.2 ± 1.2 nmol/L) participated in this study.
Intervention
An 8-hour intravenous infusion of 2 pmol/kg/min glucagon or rate-matched vehicle infusion was administered.
Main Outcome Measures
Luteinizing hormone (LH) pulsatility; LH, follicle-stimulating hormone (FSH), and testosterone levels were measured.
Results
Although glucagon administration induced metabolic effects (insulin area under the curve: vehicle 1065 ± 292 min.µU/mL vs glucagon 2098 ± 358 min.µU/mL, P < .001), it did not affect LH pulsatility (number of LH pulses/500 min: vehicle 4.7 ± 0.4, glucagon 4.2 ± 0.4, P = .22). Additionally, there were no significant differences in circulating LH, FSH, or testosterone levels during glucagon administration compared with vehicle administration.
Conclusions
Acute administration of a metabolically active dose of glucagon does not alter reproductive hormone secretion in healthy men. These data are important for the continued development of glucagon-based treatments for obesity.</description><subject>Acute effects</subject><subject>Adult</subject><subject>Biological control systems</subject><subject>Biomarkers - metabolism</subject><subject>Body mass index</subject><subject>Body weight gain</subject><subject>Clinical s</subject><subject>Cross-Over Studies</subject><subject>Energy expenditure</subject><subject>Follicle Stimulating Hormone - metabolism</subject><subject>Follicle-stimulating hormone</subject><subject>Gastrointestinal Agents - administration & dosage</subject><subject>Glucagon</subject><subject>Glucagon - administration & dosage</subject><subject>Health aspects</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypogonadism</subject><subject>Insulin</subject><subject>Intravenous administration</subject><subject>Luteinizing hormone</subject><subject>Luteinizing Hormone - drug effects</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Male</subject><subject>Obesity</subject><subject>Prognosis</subject><subject>Properties</subject><subject>Reproduction</subject><subject>Secretion</subject><subject>Single-Blind Method</subject><subject>Testosterone</subject><subject>Testosterone - metabolism</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqFkdtrFDEUxoModq2--igDvujDtieXyUxehKXUrlIRvIBvIWbO7KZmkjWZael_b7a71gsVSSCQ73e-5JyPkKcUjiijcGy9CzgcdytjqBT3yIwqUc8bqpr7ZAbA6Fw17MsBeZTzBQAVouYPyQFnjDMu-Yy8XdhpxOq079GOuYp9deYna1YxVGV_wE2K3WRHd4nVMqYhBqw-ok04uiK7UC3R-HF9Xb3D8Jg86I3P-GR_HpLPr08_nSzn5-_P3pwszue2lkzMG2gtcGRcSVXXSkkAaRsF2HPVKQ5t2_LOiBoUt0YqSpmSHCWyGxEEPySvdr6b6euAncUwJuP1JrnBpGsdjdN_KsGt9Spe6oa2jLKtwYu9QYrfJ8yjHly26L0JGKesGW9r1lBgdUGf_4VexCmF0p5mAmoupGjgF7UyHrULfSzv2q2pXkiuWgVMNIU6uoMqq8PB2TLZ3pX7uwpsijkn7G97pKC36etd-nqffil49vtkbvGfcReA7YCr6EdM-ZufrjDp9U2I_3Z9uSuK0-Z_P_gBwkvJJA</recordid><startdate>20200601</startdate><enddate>20200601</enddate><creator>Izzi-Engbeaya, Chioma</creator><creator>Jones, Sophie</creator><creator>Crustna, Yoshibye</creator><creator>Machenahalli, Pratibha C</creator><creator>Papadopoulou, Deborah</creator><creator>Modi, Manish</creator><creator>Starikova, Jessica</creator><creator>Chan, Derek</creator><creator>Eng, Pei Chia</creator><creator>Phylactou, Maria</creator><creator>Ratnasabapathy, Risheka</creator><creator>Mills, Edouard</creator><creator>Yang, Lisa</creator><creator>Pacuszka, Ewa</creator><creator>Bech, Paul</creator><creator>Minnion, James</creator><creator>Tharakan, George</creator><creator>Tan, Tricia</creator><creator>Veldhuis, Johannes</creator><creator>Abbara, Ali</creator><creator>Comninos, Alexander N</creator><creator>Dhillo, Waljit S</creator><general>Oxford University Press</general><general>Copyright Oxford University Press</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2795-5256</orcidid><orcidid>https://orcid.org/0000-0001-5950-4316</orcidid><orcidid>https://orcid.org/0000-0001-7599-0166</orcidid><orcidid>https://orcid.org/0000-0001-5873-3432</orcidid><orcidid>https://orcid.org/0000-0002-4987-1224</orcidid><orcidid>https://orcid.org/0000-0002-7104-2297</orcidid></search><sort><creationdate>20200601</creationdate><title>Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men</title><author>Izzi-Engbeaya, Chioma ; Jones, Sophie ; Crustna, Yoshibye ; Machenahalli, Pratibha C ; Papadopoulou, Deborah ; Modi, Manish ; Starikova, Jessica ; Chan, Derek ; Eng, Pei Chia ; Phylactou, Maria ; Ratnasabapathy, Risheka ; Mills, Edouard ; Yang, Lisa ; Pacuszka, Ewa ; Bech, Paul ; Minnion, James ; Tharakan, George ; Tan, Tricia ; Veldhuis, Johannes ; Abbara, Ali ; Comninos, Alexander N ; Dhillo, Waljit S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5624-708c03e2396955996006c790ef39d9308883da45093ca69112963e6e2d9308043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acute effects</topic><topic>Adult</topic><topic>Biological control systems</topic><topic>Biomarkers - metabolism</topic><topic>Body mass index</topic><topic>Body weight gain</topic><topic>Clinical s</topic><topic>Cross-Over Studies</topic><topic>Energy expenditure</topic><topic>Follicle Stimulating Hormone - metabolism</topic><topic>Follicle-stimulating hormone</topic><topic>Gastrointestinal Agents - administration & dosage</topic><topic>Glucagon</topic><topic>Glucagon - administration & dosage</topic><topic>Health aspects</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypogonadism</topic><topic>Insulin</topic><topic>Intravenous administration</topic><topic>Luteinizing hormone</topic><topic>Luteinizing Hormone - drug effects</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Male</topic><topic>Obesity</topic><topic>Prognosis</topic><topic>Properties</topic><topic>Reproduction</topic><topic>Secretion</topic><topic>Single-Blind Method</topic><topic>Testosterone</topic><topic>Testosterone - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Izzi-Engbeaya, Chioma</creatorcontrib><creatorcontrib>Jones, Sophie</creatorcontrib><creatorcontrib>Crustna, Yoshibye</creatorcontrib><creatorcontrib>Machenahalli, Pratibha C</creatorcontrib><creatorcontrib>Papadopoulou, Deborah</creatorcontrib><creatorcontrib>Modi, Manish</creatorcontrib><creatorcontrib>Starikova, Jessica</creatorcontrib><creatorcontrib>Chan, Derek</creatorcontrib><creatorcontrib>Eng, Pei Chia</creatorcontrib><creatorcontrib>Phylactou, Maria</creatorcontrib><creatorcontrib>Ratnasabapathy, Risheka</creatorcontrib><creatorcontrib>Mills, Edouard</creatorcontrib><creatorcontrib>Yang, Lisa</creatorcontrib><creatorcontrib>Pacuszka, Ewa</creatorcontrib><creatorcontrib>Bech, Paul</creatorcontrib><creatorcontrib>Minnion, James</creatorcontrib><creatorcontrib>Tharakan, George</creatorcontrib><creatorcontrib>Tan, Tricia</creatorcontrib><creatorcontrib>Veldhuis, Johannes</creatorcontrib><creatorcontrib>Abbara, Ali</creatorcontrib><creatorcontrib>Comninos, Alexander N</creatorcontrib><creatorcontrib>Dhillo, Waljit S</creatorcontrib><collection>Oxford University Press Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Databases</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Izzi-Engbeaya, Chioma</au><au>Jones, Sophie</au><au>Crustna, Yoshibye</au><au>Machenahalli, Pratibha C</au><au>Papadopoulou, Deborah</au><au>Modi, Manish</au><au>Starikova, Jessica</au><au>Chan, Derek</au><au>Eng, Pei Chia</au><au>Phylactou, Maria</au><au>Ratnasabapathy, Risheka</au><au>Mills, Edouard</au><au>Yang, Lisa</au><au>Pacuszka, Ewa</au><au>Bech, Paul</au><au>Minnion, James</au><au>Tharakan, George</au><au>Tan, Tricia</au><au>Veldhuis, Johannes</au><au>Abbara, Ali</au><au>Comninos, Alexander N</au><au>Dhillo, Waljit S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2020-06-01</date><risdate>2020</risdate><volume>105</volume><issue>6</issue><spage>1899</spage><epage>1905</epage><pages>1899-1905</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Context
Glucagon increases energy expenditure; consequently, glucagon receptor agonists are in development for the treatment of obesity. Obesity negatively affects the reproductive axis, and hypogonadism itself can exacerbate weight gain. Therefore, knowledge of the effects of glucagon receptor agonism on reproductive hormones is important for developing therapeutics for obesity; but reports in the literature about the effects of glucagon receptor agonism on the reproductive axis are conflicting.
Objective
The objective of this work is to investigate the effect of glucagon administration on reproductive hormone secretion in healthy young men.
Design
A single-blinded, randomized, placebo-controlled crossover study was conducted.
Setting
The setting of this study was the Clinical Research Facility, Imperial College Healthcare NHS Trust.
Participants
Eighteen healthy eugonadal men (mean ± SEM: age 25.1 ± 1.0 years; body mass index 22.5 ± 0.4 kg/m2; testosterone 21.2 ± 1.2 nmol/L) participated in this study.
Intervention
An 8-hour intravenous infusion of 2 pmol/kg/min glucagon or rate-matched vehicle infusion was administered.
Main Outcome Measures
Luteinizing hormone (LH) pulsatility; LH, follicle-stimulating hormone (FSH), and testosterone levels were measured.
Results
Although glucagon administration induced metabolic effects (insulin area under the curve: vehicle 1065 ± 292 min.µU/mL vs glucagon 2098 ± 358 min.µU/mL, P < .001), it did not affect LH pulsatility (number of LH pulses/500 min: vehicle 4.7 ± 0.4, glucagon 4.2 ± 0.4, P = .22). Additionally, there were no significant differences in circulating LH, FSH, or testosterone levels during glucagon administration compared with vehicle administration.
Conclusions
Acute administration of a metabolically active dose of glucagon does not alter reproductive hormone secretion in healthy men. These data are important for the continued development of glucagon-based treatments for obesity.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>32232363</pmid><doi>10.1210/clinem/dgaa164</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-2795-5256</orcidid><orcidid>https://orcid.org/0000-0001-5950-4316</orcidid><orcidid>https://orcid.org/0000-0001-7599-0166</orcidid><orcidid>https://orcid.org/0000-0001-5873-3432</orcidid><orcidid>https://orcid.org/0000-0002-4987-1224</orcidid><orcidid>https://orcid.org/0000-0002-7104-2297</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2020-06, Vol.105 (6), p.1899-1905 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7182124 |
| source | Oxford Journals Online |
| subjects | Acute effects Adult Biological control systems Biomarkers - metabolism Body mass index Body weight gain Clinical s Cross-Over Studies Energy expenditure Follicle Stimulating Hormone - metabolism Follicle-stimulating hormone Gastrointestinal Agents - administration & dosage Glucagon Glucagon - administration & dosage Health aspects Hormones Humans Hypogonadism Insulin Intravenous administration Luteinizing hormone Luteinizing Hormone - drug effects Luteinizing Hormone - metabolism Male Obesity Prognosis Properties Reproduction Secretion Single-Blind Method Testosterone Testosterone - metabolism |
| title | Acute Effects of Glucagon on Reproductive Hormone Secretion in Healthy Men |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T22%3A35%3A09IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20Effects%20of%20Glucagon%20on%20Reproductive%20Hormone%20Secretion%20in%20Healthy%20Men&rft.jtitle=The%20journal%20of%20clinical%20endocrinology%20and%20metabolism&rft.au=Izzi-Engbeaya,%20Chioma&rft.date=2020-06-01&rft.volume=105&rft.issue=6&rft.spage=1899&rft.epage=1905&rft.pages=1899-1905&rft.issn=0021-972X&rft.eissn=1945-7197&rft_id=info:doi/10.1210/clinem/dgaa164&rft_dat=%3Cgale_pubme%3EA639890247%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5624-708c03e2396955996006c790ef39d9308883da45093ca69112963e6e2d9308043%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2405346470&rft_id=info:pmid/32232363&rft_galeid=A639890247&rft_oup_id=10.1210/clinem/dgaa164&rfr_iscdi=true |