Clinical Outcomes in 55 Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Who Were Asymptomatic at Hospital Admission in Shenzhen, China

Abstract An epidemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread unexpectedly in Wuhan, Hubei Province, China, since December 2019. There are few reports about asymptomatic contacts of infected patients identified as positive for SARS-CoV-2 through scr...

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Bibliographic Details
Published in:The Journal of Infectious Diseases 2020-05, Vol.221 (11), p.1770-1774
Main Authors: Wang, Yanrong, Liu, Yingxia, Liu, Lei, Wang, Xianfeng, Luo, Nijuan, Li, Ling
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antiviral Agents - therapeutic use
Asymptomatic
Asymptomatic Infections
Betacoronavirus
Brief Report
Child
Child, Preschool
China - epidemiology
Clinical outcomes
Coronaviridae
Coronavirus Infections - drug therapy
Coronavirus Infections - epidemiology
Coronavirus Infections - pathology
Coronaviruses
COVID-19
Disease Progression
Drug Combinations
Epidemiology
Female
Hospitalization
Hospitalization - statistics & numerical data
Humans
Lopinavir - therapeutic use
Male
Middle Aged
Pandemics
Patients
Pharynx
Pneumonia, Viral - drug therapy
Pneumonia, Viral - epidemiology
Pneumonia, Viral - pathology
Retrospective Studies
Ritonavir - therapeutic use
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Time Factors
Treatment Outcome
Young Adult
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Summary:Abstract An epidemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread unexpectedly in Wuhan, Hubei Province, China, since December 2019. There are few reports about asymptomatic contacts of infected patients identified as positive for SARS-CoV-2 through screening. We studied the epidemiological and clinical outcomes in 55 asymptomatic carriers who were laboratory confirmed to be positive for SARS-CoV-2 through nucleic acid testing of pharyngeal swab samples. The asymptomatic carriers seldom occurred among young people (aged 18–29 years) who had close contact with infected family members. In the majority of patients, the outcome was mild or ordinary 2019 novel coronavirus disease during hospitalization. Severe acute respiratory syndrome coronavirus 2 carriers occurred more often in middle-aged people who had close contact with infected family members. In most infected patients who are asymptomatic at the time of hospital admission, mild or ordinary 2019 novel coronavirus disease will develop during hospitalization.
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jiaa119