Role of OPRM1, clinical and anthropometric variants in neonatal pain reduction

An increased awareness on neonatal pain-associated complications has led to the development of pain scales adequate to assess the level of pain experienced by newborns such as the ABC score. A commonly used analgesic procedure is to administer a 33% oral dextrose solution to newborns prior to the pa...

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Bibliographic Details
Published in:Scientific reports 2020-04, Vol.10 (1), p.7091-7091, Article 7091
Main Authors: Erbi, Ilaria, Ciantelli, Massimiliano, Farinella, Riccardo, Tuoni, Cristina, Gentiluomo, Manuel, Moscuzza, Francesca, Rizzato, Cosmeri, Bedini, Alice, Faraoni, Maddalena, Giusfredi, Stefano, Tavanti, Arianna, Ghirri, Paolo, Campa, Daniele
Format: Article
Language:English
Subjects:
45/77
631/208/205
631/208/212/1728
Analgesics
Body measurements
Dextrose
Female
Genetic variability
Genotype
Genotypes
Humanities and Social Sciences
Humans
Infant, Newborn
Infant, Newborn, Diseases - genetics
Infant, Newborn, Diseases - physiopathology
Infant, Newborn, Diseases - therapy
Male
multidisciplinary
Neonates
Pain
Pain - genetics
Pain - physiopathology
Pain Management
Polymorphism, Single Nucleotide
Receptors, Opioid, mu
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
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Summary:An increased awareness on neonatal pain-associated complications has led to the development of pain scales adequate to assess the level of pain experienced by newborns such as the ABC score. A commonly used analgesic procedure is to administer a 33% oral dextrose solution to newborns prior to the painful intervention. Although this procedure is very successful, not in all subjects it reaches complete efficacy. A possible explanation for the different response to the treatment could be genetic variability. We have investigated the genetic variability of the OPRM1 gene in 1077 newborns in relation to non-pharmacologic pain relief treatment. We observed that the procedure was successful in 966 individuals and there was no association between the genotypes and the analgesic efficacy when comparing individuals that had an ABC score = 0 and ABC score >0. However, considering only the individuals with ABC score>0, we found that the homozygous carriers of the G allele of the missense variant SNP rs1799971 (A118G) showed an interesting association with higher ABC score. We also observed that individuals fed with formula milk were more likely to not respond to the analgesic treatment compared to those that had been breastfed.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-63790-2