Loading…

Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC])

Genetic variations of breast cancer survivors (BCS) may contribute to level of residual symptoms, such as depression, stress, fatigue, and cognitive impairment. The objective of this study was to investigate whether particular single-nucleotide polymorphisms (SNPs) moderated symptom improvement resu...

Full description

Saved in:
Bibliographic Details
Published in:Translational behavioral medicine 2019-08, Vol.9 (4), p.693-702
Main Authors: Park, Jong Y, Lengacher, Cecile A, Reich, Richard R, Alinat, Carissa B, Ramesar, Sophia, Le, Alice, Paterson, Carly L, Pleasant, Michelle L, Park, Hyun Y, Kiluk, John, Han, Hyo, Ismail-Khan, Roohi, Kip, Kevin E
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c445t-1f3e868b32b79ba023bf121cabc92435af7f3c835f9499bb87c625c1023184bc3
cites cdi_FETCH-LOGICAL-c445t-1f3e868b32b79ba023bf121cabc92435af7f3c835f9499bb87c625c1023184bc3
container_end_page 702
container_issue 4
container_start_page 693
container_title Translational behavioral medicine
container_volume 9
creator Park, Jong Y
Lengacher, Cecile A
Reich, Richard R
Alinat, Carissa B
Ramesar, Sophia
Le, Alice
Paterson, Carly L
Pleasant, Michelle L
Park, Hyun Y
Kiluk, John
Han, Hyo
Ismail-Khan, Roohi
Kip, Kevin E
description Genetic variations of breast cancer survivors (BCS) may contribute to level of residual symptoms, such as depression, stress, fatigue, and cognitive impairment. The objective of this study was to investigate whether particular single-nucleotide polymorphisms (SNPs) moderated symptom improvement resulting from the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program. An overarching goal of personalized medicine is to identify individuals as risk for disease and tailor interventions based on genetic profiles of patients with diseases including cancer. BCS were recruited from Moffitt Cancer Center and University of South Florida’s Breast Health Program and were randomized to either the 6-week MBSR(BC) program (n = 92) or Usual Care (n = 93). Measures of symptoms, demographic, and clinical history data were attained at baseline, 6 weeks, and 12 weeks. A total of 10 SNPs from eight genes known to be related to these symptoms were studied using genomic DNA extracted from blood. Our results were examined for effect sizes, consistency, and statistical significance (p < .05). Three SNPs (rs4680 in COMT, rs6314 in HTR2A, and rs429358 in APOE) emerged as having the strongest (though relatively weak) and most consistent effects in moderating the impact of the MBSR program on symptom outcomes. Although effects were generally weak, with only one effect withstanding multiple comparisons correction for statistical significance, this translational behavioral research may help start the identification of genetic profiles that moderate the impact of MBSR(BC). The ultimate goal of this study is the development of personalized treatment programs tailored to the genetic profile of each patient.
doi_str_mv 10.1093/tbm/iby061
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7184864</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A640512367</galeid><sourcerecordid>A640512367</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-1f3e868b32b79ba023bf121cabc92435af7f3c835f9499bb87c625c1023184bc3</originalsourceid><addsrcrecordid>eNptkV1LBCEYhSWKiuqmXyB0U8GUjjM600WwLX1BEfRxFSFqOmuMOui0sP36XDaCIL3wxfOcg3gA2MfoBKOWnI7SnVq5QBSvgW1MMSnahqL1PDe0LSjDdAvspfSB8qpoiRneBFsEYcIoYtvg6zkKn3ox2uBFDzvtg7MKRp20iGp2BseZhjH0GgazVPWY1SH0CxfiMLPJJWg9vL94eoRDDF0UDgoXfAdl1CKNUAmvdITpM87tPMQED5fs68X07WgXbBjRJ733c-6Al6vL5-lNcfdwfTud3BWqquqxwIbohjaSlJK1UqCSSINLrIRUbVmRWhhmiGpIbdqqbaVsmKJlrXAGcVNJRXbA-Sp3-JROvyvtxyh6PkTrRFzwICz_q3g7412Yc5b9Da1ywMEqoBO95tabkDHlbFJ8QitU45JQlqmTf6i833X-0eC1sfn-j-F4ZVAxpBS1-X0SRnzZLc_d8lW35Bui_Jd-</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC])</title><source>Oxford Journals Online</source><creator>Park, Jong Y ; Lengacher, Cecile A ; Reich, Richard R ; Alinat, Carissa B ; Ramesar, Sophia ; Le, Alice ; Paterson, Carly L ; Pleasant, Michelle L ; Park, Hyun Y ; Kiluk, John ; Han, Hyo ; Ismail-Khan, Roohi ; Kip, Kevin E</creator><creatorcontrib>Park, Jong Y ; Lengacher, Cecile A ; Reich, Richard R ; Alinat, Carissa B ; Ramesar, Sophia ; Le, Alice ; Paterson, Carly L ; Pleasant, Michelle L ; Park, Hyun Y ; Kiluk, John ; Han, Hyo ; Ismail-Khan, Roohi ; Kip, Kevin E</creatorcontrib><description>Genetic variations of breast cancer survivors (BCS) may contribute to level of residual symptoms, such as depression, stress, fatigue, and cognitive impairment. The objective of this study was to investigate whether particular single-nucleotide polymorphisms (SNPs) moderated symptom improvement resulting from the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program. An overarching goal of personalized medicine is to identify individuals as risk for disease and tailor interventions based on genetic profiles of patients with diseases including cancer. BCS were recruited from Moffitt Cancer Center and University of South Florida’s Breast Health Program and were randomized to either the 6-week MBSR(BC) program (n = 92) or Usual Care (n = 93). Measures of symptoms, demographic, and clinical history data were attained at baseline, 6 weeks, and 12 weeks. A total of 10 SNPs from eight genes known to be related to these symptoms were studied using genomic DNA extracted from blood. Our results were examined for effect sizes, consistency, and statistical significance (p &lt; .05). Three SNPs (rs4680 in COMT, rs6314 in HTR2A, and rs429358 in APOE) emerged as having the strongest (though relatively weak) and most consistent effects in moderating the impact of the MBSR program on symptom outcomes. Although effects were generally weak, with only one effect withstanding multiple comparisons correction for statistical significance, this translational behavioral research may help start the identification of genetic profiles that moderate the impact of MBSR(BC). The ultimate goal of this study is the development of personalized treatment programs tailored to the genetic profile of each patient.</description><identifier>ISSN: 1869-6716</identifier><identifier>EISSN: 1613-9860</identifier><identifier>DOI: 10.1093/tbm/iby061</identifier><identifier>PMID: 30137607</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Breast cancer ; Cancer survivors ; Genetic aspects ; Genetic polymorphisms ; Genetic variation ; Health aspects ; Original Research</subject><ispartof>Translational behavioral medicine, 2019-08, Vol.9 (4), p.693-702</ispartof><rights>COPYRIGHT 2019 Oxford University Press</rights><rights>Society of Behavioral Medicine 2018. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-1f3e868b32b79ba023bf121cabc92435af7f3c835f9499bb87c625c1023184bc3</citedby><cites>FETCH-LOGICAL-c445t-1f3e868b32b79ba023bf121cabc92435af7f3c835f9499bb87c625c1023184bc3</cites><orcidid>0000-0003-2700-2367</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids></links><search><creatorcontrib>Park, Jong Y</creatorcontrib><creatorcontrib>Lengacher, Cecile A</creatorcontrib><creatorcontrib>Reich, Richard R</creatorcontrib><creatorcontrib>Alinat, Carissa B</creatorcontrib><creatorcontrib>Ramesar, Sophia</creatorcontrib><creatorcontrib>Le, Alice</creatorcontrib><creatorcontrib>Paterson, Carly L</creatorcontrib><creatorcontrib>Pleasant, Michelle L</creatorcontrib><creatorcontrib>Park, Hyun Y</creatorcontrib><creatorcontrib>Kiluk, John</creatorcontrib><creatorcontrib>Han, Hyo</creatorcontrib><creatorcontrib>Ismail-Khan, Roohi</creatorcontrib><creatorcontrib>Kip, Kevin E</creatorcontrib><title>Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC])</title><title>Translational behavioral medicine</title><description>Genetic variations of breast cancer survivors (BCS) may contribute to level of residual symptoms, such as depression, stress, fatigue, and cognitive impairment. The objective of this study was to investigate whether particular single-nucleotide polymorphisms (SNPs) moderated symptom improvement resulting from the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program. An overarching goal of personalized medicine is to identify individuals as risk for disease and tailor interventions based on genetic profiles of patients with diseases including cancer. BCS were recruited from Moffitt Cancer Center and University of South Florida’s Breast Health Program and were randomized to either the 6-week MBSR(BC) program (n = 92) or Usual Care (n = 93). Measures of symptoms, demographic, and clinical history data were attained at baseline, 6 weeks, and 12 weeks. A total of 10 SNPs from eight genes known to be related to these symptoms were studied using genomic DNA extracted from blood. Our results were examined for effect sizes, consistency, and statistical significance (p &lt; .05). Three SNPs (rs4680 in COMT, rs6314 in HTR2A, and rs429358 in APOE) emerged as having the strongest (though relatively weak) and most consistent effects in moderating the impact of the MBSR program on symptom outcomes. Although effects were generally weak, with only one effect withstanding multiple comparisons correction for statistical significance, this translational behavioral research may help start the identification of genetic profiles that moderate the impact of MBSR(BC). The ultimate goal of this study is the development of personalized treatment programs tailored to the genetic profile of each patient.</description><subject>Breast cancer</subject><subject>Cancer survivors</subject><subject>Genetic aspects</subject><subject>Genetic polymorphisms</subject><subject>Genetic variation</subject><subject>Health aspects</subject><subject>Original Research</subject><issn>1869-6716</issn><issn>1613-9860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNptkV1LBCEYhSWKiuqmXyB0U8GUjjM600WwLX1BEfRxFSFqOmuMOui0sP36XDaCIL3wxfOcg3gA2MfoBKOWnI7SnVq5QBSvgW1MMSnahqL1PDe0LSjDdAvspfSB8qpoiRneBFsEYcIoYtvg6zkKn3ox2uBFDzvtg7MKRp20iGp2BseZhjH0GgazVPWY1SH0CxfiMLPJJWg9vL94eoRDDF0UDgoXfAdl1CKNUAmvdITpM87tPMQED5fs68X07WgXbBjRJ733c-6Al6vL5-lNcfdwfTud3BWqquqxwIbohjaSlJK1UqCSSINLrIRUbVmRWhhmiGpIbdqqbaVsmKJlrXAGcVNJRXbA-Sp3-JROvyvtxyh6PkTrRFzwICz_q3g7412Yc5b9Da1ywMEqoBO95tabkDHlbFJ8QitU45JQlqmTf6i833X-0eC1sfn-j-F4ZVAxpBS1-X0SRnzZLc_d8lW35Bui_Jd-</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Park, Jong Y</creator><creator>Lengacher, Cecile A</creator><creator>Reich, Richard R</creator><creator>Alinat, Carissa B</creator><creator>Ramesar, Sophia</creator><creator>Le, Alice</creator><creator>Paterson, Carly L</creator><creator>Pleasant, Michelle L</creator><creator>Park, Hyun Y</creator><creator>Kiluk, John</creator><creator>Han, Hyo</creator><creator>Ismail-Khan, Roohi</creator><creator>Kip, Kevin E</creator><general>Oxford University Press</general><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2700-2367</orcidid></search><sort><creationdate>20190801</creationdate><title>Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC])</title><author>Park, Jong Y ; Lengacher, Cecile A ; Reich, Richard R ; Alinat, Carissa B ; Ramesar, Sophia ; Le, Alice ; Paterson, Carly L ; Pleasant, Michelle L ; Park, Hyun Y ; Kiluk, John ; Han, Hyo ; Ismail-Khan, Roohi ; Kip, Kevin E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-1f3e868b32b79ba023bf121cabc92435af7f3c835f9499bb87c625c1023184bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Breast cancer</topic><topic>Cancer survivors</topic><topic>Genetic aspects</topic><topic>Genetic polymorphisms</topic><topic>Genetic variation</topic><topic>Health aspects</topic><topic>Original Research</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Jong Y</creatorcontrib><creatorcontrib>Lengacher, Cecile A</creatorcontrib><creatorcontrib>Reich, Richard R</creatorcontrib><creatorcontrib>Alinat, Carissa B</creatorcontrib><creatorcontrib>Ramesar, Sophia</creatorcontrib><creatorcontrib>Le, Alice</creatorcontrib><creatorcontrib>Paterson, Carly L</creatorcontrib><creatorcontrib>Pleasant, Michelle L</creatorcontrib><creatorcontrib>Park, Hyun Y</creatorcontrib><creatorcontrib>Kiluk, John</creatorcontrib><creatorcontrib>Han, Hyo</creatorcontrib><creatorcontrib>Ismail-Khan, Roohi</creatorcontrib><creatorcontrib>Kip, Kevin E</creatorcontrib><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational behavioral medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Jong Y</au><au>Lengacher, Cecile A</au><au>Reich, Richard R</au><au>Alinat, Carissa B</au><au>Ramesar, Sophia</au><au>Le, Alice</au><au>Paterson, Carly L</au><au>Pleasant, Michelle L</au><au>Park, Hyun Y</au><au>Kiluk, John</au><au>Han, Hyo</au><au>Ismail-Khan, Roohi</au><au>Kip, Kevin E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC])</atitle><jtitle>Translational behavioral medicine</jtitle><date>2019-08-01</date><risdate>2019</risdate><volume>9</volume><issue>4</issue><spage>693</spage><epage>702</epage><pages>693-702</pages><issn>1869-6716</issn><eissn>1613-9860</eissn><abstract>Genetic variations of breast cancer survivors (BCS) may contribute to level of residual symptoms, such as depression, stress, fatigue, and cognitive impairment. The objective of this study was to investigate whether particular single-nucleotide polymorphisms (SNPs) moderated symptom improvement resulting from the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR[BC]) program. An overarching goal of personalized medicine is to identify individuals as risk for disease and tailor interventions based on genetic profiles of patients with diseases including cancer. BCS were recruited from Moffitt Cancer Center and University of South Florida’s Breast Health Program and were randomized to either the 6-week MBSR(BC) program (n = 92) or Usual Care (n = 93). Measures of symptoms, demographic, and clinical history data were attained at baseline, 6 weeks, and 12 weeks. A total of 10 SNPs from eight genes known to be related to these symptoms were studied using genomic DNA extracted from blood. Our results were examined for effect sizes, consistency, and statistical significance (p &lt; .05). Three SNPs (rs4680 in COMT, rs6314 in HTR2A, and rs429358 in APOE) emerged as having the strongest (though relatively weak) and most consistent effects in moderating the impact of the MBSR program on symptom outcomes. Although effects were generally weak, with only one effect withstanding multiple comparisons correction for statistical significance, this translational behavioral research may help start the identification of genetic profiles that moderate the impact of MBSR(BC). The ultimate goal of this study is the development of personalized treatment programs tailored to the genetic profile of each patient.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>30137607</pmid><doi>10.1093/tbm/iby061</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2700-2367</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1869-6716
ispartof Translational behavioral medicine, 2019-08, Vol.9 (4), p.693-702
issn 1869-6716
1613-9860
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7184864
source Oxford Journals Online
subjects Breast cancer
Cancer survivors
Genetic aspects
Genetic polymorphisms
Genetic variation
Health aspects
Original Research
title Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC])
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T20%3A47%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Translational%20genomic%20research:%20the%20role%20of%20genetic%20polymorphisms%20in%20MBSR%20program%20among%20breast%20cancer%20survivors%20(MBSR%5BBC%5D)&rft.jtitle=Translational%20behavioral%20medicine&rft.au=Park,%20Jong%20Y&rft.date=2019-08-01&rft.volume=9&rft.issue=4&rft.spage=693&rft.epage=702&rft.pages=693-702&rft.issn=1869-6716&rft.eissn=1613-9860&rft_id=info:doi/10.1093/tbm/iby061&rft_dat=%3Cgale_pubme%3EA640512367%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c445t-1f3e868b32b79ba023bf121cabc92435af7f3c835f9499bb87c625c1023184bc3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/30137607&rft_galeid=A640512367&rfr_iscdi=true