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miR-454 promotes survival and induces oxaliplatin resistance in gastric carcinoma cells by targeting CYLD

MicroRNA-454 (miR-454), is involved in the progression of various types of cancers. The present study aimed to evaluate the effect of miR-454 on the progression of gastric cancer. SGC-7901 cells overexpressing or silencing miR454 were constructed via transfection and the survival rate of the cells w...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2020-06, Vol.19 (6), p.3604-3610
Main Authors: Huang, Chaoqun, Liu, Jiuyang, Pan, Xuekai, Peng, Chunwei, Xiong, Bin, Feng, Maohui, Yang, Xiaojun
Format: Article
Language:English
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Summary:MicroRNA-454 (miR-454), is involved in the progression of various types of cancers. The present study aimed to evaluate the effect of miR-454 on the progression of gastric cancer. SGC-7901 cells overexpressing or silencing miR454 were constructed via transfection and the survival rate of the cells was determined. The relationship between miR-454 and cylindromatosis (CYLD) was explored and the influence of miR-454 on oxaliplatin resistance was investigated in SGC-7901 cells. It was determined that overexpression of miR-454 increased the number of colonies and reduced apoptosis rate of SGC-7901 cells. The CYLD gene was identified as a direct target of miR-454. miR-454 overexpression downregulated the expression of CYLD, leading to an increase in SGC-7901 cell proliferation. Finally, miR-454 was also demonstrated to induce resistance to oxaliplatin in gastric cancer cells. In conclusion, the present findings suggested that miR-454 might be a novel therapeutic target for gastric cancer.
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2020.8655