Multi-focal Lytic Lesions in a Patient with Myelofibrosis: A Case Report

Myelofibrosis is a rare disorder that is classified as one of the myeloproliferative disorders. This particular disorder results in the abnormal proliferation of hematopoietic stem cells in the bone marrow. In some cases, such as ours, pathologic fractures can occur due to skeletal manifestations. W...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-03, Vol.12 (3), p.e7475
Main Authors: Burnham, Jr, Robert R, Johnson, Bailey, Lomasney, Laurie M, Borys, Dariusz, Cooper, Anna R
Format: Article
Language:English
Subjects:
Bone marrow
Case reports
Hemoglobin
Leukemia
Medical prognosis
Metastasis
Multiple myeloma
Mutation
Oncology
Orthopedics
Pain
Pathology
Patients
Radiation therapy
Shoulder
Uric acid
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Summary:Myelofibrosis is a rare disorder that is classified as one of the myeloproliferative disorders. This particular disorder results in the abnormal proliferation of hematopoietic stem cells in the bone marrow. In some cases, such as ours, pathologic fractures can occur due to skeletal manifestations. We report on a rare finding of rapidly progressive lytic lesions in multiple regions throughout the body. This presentation of myelofibrosis behaving in a metastatic-like fashion has not been previously described.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.7475