Associations of accelerometer-measured physical activity and physical activity-related cancer incidence in older women: results from the WHI OPACH Study

Background We examined the associations between accelerometry-measured physical activity (PA) and incidence of 13 cancers among a cohort of postmenopausal women. Methods In this prospective study, 6382 women wore ActiGraph GT3X+ accelerometers at the hip for up to 7 days during 2012–2013, and were f...

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Bibliographic Details
Published in:British journal of cancer 2020-04, Vol.122 (9), p.1409-1416
Main Authors: Parada, Humberto, McDonald, Emily, Bellettiere, John, Evenson, Kelly R., LaMonte, Michael J., LaCroix, Andrea Z.
Format: Article
Language:English
Subjects:
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Accelerometry
Age
Aged
Aged, 80 and over
Biomedical and Life Sciences
Biomedicine
Body Mass Index
Cancer Research
Drug Resistance
Epidemiology
Ethnicity
Exercise
Exercise - physiology
Female
Health risk assessment
Hip
Humans
Invasiveness
Middle Aged
Minority & ethnic groups
Molecular Medicine
Neoplasms - epidemiology
Neoplasms - etiology
Neoplasms - pathology
Older people
Oncology
Physical activity
Post-menopause
Proportional Hazards Models
Sedentary Behavior
Smoking
Smoking - adverse effects
Women
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Summary:Background We examined the associations between accelerometry-measured physical activity (PA) and incidence of 13 cancers among a cohort of postmenopausal women. Methods In this prospective study, 6382 women wore ActiGraph GT3X+ accelerometers at the hip for up to 7 days during 2012–2013, and were followed over a median of 4.7 years for diagnosis of 13 invasive cancers. Calibrated intensity cut points were used to define minutes per day of total, light and moderate-to-vigorous PA. We used multivariable Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for tertiles, and one-standard deviation (SD) unit increments of PA exposures in relation to cancer incidence. We examined effect measure modification by age, race/ethnicity, body mass index and smoking history. Results The highest (vs. lowest) tertiles of total, light and moderate-to-vigorous PA were associated with covariate-adjusted HRs of 0.72 (95% CI = 0.53–0.97), 0.81 (95% CI = 0.60–1.09) and 0.66 (95% CI = 0.48–0.91), respectively. In age-stratified analyses, HRs for total PA were lower among women
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-020-0753-6