Risk Factors for Human Papillomavirus Infection and Abnormal Cervical Cytology Among Perinatally Human Immunodeficiency Virus-Infected and Uninfected Asian Youth

In an observational study of perinatally human immunodeficiency virus (HIV)-infected (PHIV) adolescents matched by age and sexual activity to uninfected females in Thailand and Vietnam, PHIV adolescents had higher rates of anogenital infection with high-risk human papillomavirus and abnormal cervica...

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Bibliographic Details
Published in:Clinical infectious diseases 2018-08, Vol.67 (4), p.606-613
Main Authors: Sohn, Annette H, Kerr, Stephen J, Hansudewechakul, Rawiwan, Gatechompol, Sivaporn, Chokephaibulkit, Kulkanya, Dang, Hanh Le Dung, Tran, Dan Ngoc Hanh, Achalapong, Jullapong, Teeratakulpisarn, Nipat, Chalermchockcharoenkit, Amphan, Thamkhantho, Manopchai, Pankam, Tippawan, Singtoroj, Thida, Termrungruanglert, Wichai, Chaithongwongwatthana, Surasith, Phanuphak, Nittaya
Format: Article
Language:English
Subjects:
Adolescent
and Commentaries
CD4 Lymphocyte Count
Cervix Uteri - pathology
Female
HIV - isolation & purification
HIV Infections - complications
HIV Infections - epidemiology
Humans
Longitudinal Studies
Papillomavirus Infections - epidemiology
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - virology
Risk Factors
Sexually Transmitted Diseases - complications
Sexually Transmitted Diseases - epidemiology
Thailand - epidemiology
Vaginal Smears
Vietnam - epidemiology
Viral Load
Young Adult
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Summary:In an observational study of perinatally human immunodeficiency virus (HIV)-infected (PHIV) adolescents matched by age and sexual activity to uninfected females in Thailand and Vietnam, PHIV adolescents had higher rates of anogenital infection with high-risk human papillomavirus and abnormal cervical Pap smears. Abstract Background Infection with high-risk human papillomavirus (HR-HPV) may be higher in perinatally human immunodeficiency virus (HIV)-infected (PHIV) than HIV-uninfected (HU) adolescents because of long-standing immune deficiency. Methods PHIV and HU females aged 12-24 years in Thailand and Vietnam were matched by age group and lifetime sexual partners. At enrollment, blood, cervical, vaginal, anal, and oral samples were obtained for HPV-related testing. The Wilcoxon and Fisher exact tests were used for univariate and logistic regression for multivariate analyses. Results Ninety-three PHIV and 99 HU adolescents (median age 19 [18-20] years) were enrolled (June 2013-July 2015). Among PHIV, 94% were currently receiving antiretroviral therapy, median CD4 count was 593 (392-808) cells/mm3, and 62% had a viral load
ISSN:1058-4838
1537-6591
DOI:10.1093/cid/ciy144