Neuroimmune modulation of pain and regenerative pain medicine

Regenerative pain medicine, which seeks to harness the body's own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we d...

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Bibliographic Details
Published in:The Journal of clinical investigation 2020-05, Vol.130 (5), p.2164-2176
Main Authors: Buchheit, Thomas, Huh, Yul, Maixner, William, Cheng, Jianguo, Ji, Ru-Rong
Format: Article
Language:English
Subjects:
Analgesics
Animals
Arthritis
Autism
Biomedical research
Chemotherapy
Chronic pain
Chronic Pain - immunology
Chronic Pain - therapy
Epigenetics
Gene expression
Humans
Ligands
Medicine
Narcotics
Neuroimmunomodulation
Neuromodulation
Neurons
Neurophysiology
Pain
Pain perception
Phosphorylation
Proteins
Regenerative Medicine
Review
Spinal cord
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Summary:Regenerative pain medicine, which seeks to harness the body's own reparative capacity, is rapidly emerging as a field within pain medicine and orthopedics. It is increasingly appreciated that common analgesic mechanisms for these treatments depend on neuroimmune modulation. In this Review, we discuss recent progress in mechanistic understanding of nociceptive sensitization in chronic pain with a focus on neuroimmune modulation. We also examine the spectrum of regenerative outcomes, including preclinical and clinical outcomes. We further distinguish the analgesic mechanisms of regenerative therapies from those of cellular replacement, creating a conceptual and mechanistic framework to evaluate future research on regenerative medicine.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI134439