Lung transplant infection

ABSTRACT Lung transplantation has become an accepted therapeutic procedure for the treatment of end‐stage pulmonary parenchymal and vascular disease. Despite improved survival rates over the decades, lung transplant recipients have lower survival rates than other solid organ transplant recipients. T...

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Published in:Respirology (Carlton, Vic.) Vic.), 2013-01, Vol.18 (1), p.22-38
Main Authors: BURGUETE, SERGIO R., MASELLI, DIEGO J., FERNANDEZ, JUAN F., LEVINE, STEPHANIE M.
Format: Article
Language:English
Subjects:
Aspergillus
Bacterial Infections - epidemiology
Bacterial Infections - etiology
bacterial pneumonia
cytomegalovirus
Graft Rejection - epidemiology
Graft Rejection - microbiology
Humans
immunosuppression
INVITED REVIEW SERIES
Invited Review Series: Translating Research into Practice
Lung - microbiology
Lung Diseases - surgery
lung transplantation
Lung Transplantation - adverse effects
Mycoses - epidemiology
Mycoses - etiology
Postoperative Complications - epidemiology
Postoperative Complications - microbiology
Risk Factors
Virus Diseases - epidemiology
Virus Diseases - etiology
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Summary:ABSTRACT Lung transplantation has become an accepted therapeutic procedure for the treatment of end‐stage pulmonary parenchymal and vascular disease. Despite improved survival rates over the decades, lung transplant recipients have lower survival rates than other solid organ transplant recipients. The morbidity and mortality following lung transplantation is largely due to infection‐ and rejection‐related complications. This article will review the common infections that develop in the lung transplant recipient, including the general risk factors for infection in this population, and the most frequent bacterial, viral, fungal and other less frequent opportunistic infections. The epidemiology, diagnosis, prophylaxis, treatment and outcomes for the different microbial pathogens will be reviewed. The effects of infection on lung transplant rejection will also be discussed.
ISSN:1323-7799
1440-1843
DOI:10.1111/j.1440-1843.2012.02196.x